Publications by authors named "Fa-Ying Zhou"
Objective: To explore associations of serum neurofilament light chain (sNfL) at admission with clinical deficits and the long-term prognosis of acute ischaemic stroke (AIS).
Methods: We recruited 110 AIS patients with serum sampled at hospital arrival. The concentrations of sNfL were detected by a Simoa HD-1 analyser.
Background: Recent studies have shown that monocytes can phagocytize the tau protein, which may ameliorate tau-type pathology in Alzheimer's disease (AD). However, there are few clinical studies on the relationship between monocytes and tau-type pathology in AD patients.
Objective: We aimed to explore changes in peripheral monocytes and their association with tau protein in AD patients.
Background: Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease (AD). This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population.
Methods: We enrolled 55 AD patients and 55 age- and gender-matched cognitively normal (CN) subjects in a case-control study, as well as a cohort of 131 participants without subjective cognitive decline (non-AD) in a cross-sectional study.
LincRNA Plays a Role in the Effect of Polymorphism in Alzheimer's Disease - Related Pathology.
Front Aging Neurosci
January 2020
Polymorphism of the cholesterol-24S-hydroxylase () gene is thought to be a risk factor for Alzheimer's disease (AD). A single nucleotide polymorphism (T/C) in intron 2, rs754203, has been confirmed to be implicated in AD. Rs754203 is located in the long intronic non-coding RNA (LincRNA) sequence, which has previously been shown to be involved in the pathology of many diseases.
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- Parkinson's disease (PD) is influenced by complex interactions between genetic, environmental, and lifestyle factors, and researchers aimed to understand how genetic profiles affect PD development and biomarkers.
- A study involving 418 PD patients and 426 healthy controls analyzed 46 specific genetic variants, known as single nucleotide polymorphisms (SNPs), previously linked to PD through genome-wide association studies.
- Results indicated that certain SNPs were significantly correlated with PD in a Chinese population, and the polygenic risk score (PRS) model showed predictive value for PD risk and the age of onset, although CSF α-synuclein levels did not correlate with the PRS in normal subjects.
Brain amyloid-β (Aβ) deposition is a hallmark to define Alzheimer's disease (AD). We investigated the positive rate of brain amyloid deposition assessed with 11C-Pittsburgh compound (PiB)-PET and blood Aβ levels in a cohort of probable AD patients who were diagnosed according to the 1984 NINCDS-ADRDA criteria. Eighty-four subjects with a clinical diagnosis of probable AD dementia, amnestic mild cognitive impairment (MCI), and cognitively normal (CN) status were subjected to PiB-PET and 18F-fluorodeoxyglucose (FDG)-PET scans.
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- - Parkinson's disease is linked to the loss of dopamine neurons in the substantia nigra, with the p75 neurotrophin receptor playing a crucial role in neuronal death and disease development.
- - A case-control study involving 414 PD patients and 623 matched controls in a Chinese Han cohort investigated the relationship between NGFR gene polymorphism and PD susceptibility, using tag-SNPs for genetic assessment.
- - The findings indicated that specific tag-SNPs, particularly rs741073 and rs1804011, were associated with a reduced risk of PD across several genetic models, but these significant associations were not confirmed after applying a correction for multiple testing.