Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue.

Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu , published in the . We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia.