Meroterpenoids with Immunosuppressive Activity from Edible Fungus .

Two unusual polyketide-sesquiterpene metabolites, craterodoratins T () and U (), along with the known compound craterellin A (), were isolated from the higher fungus . The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound possessed a rare structure with two aromatic groups.

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).

Fungi have traditionally been a very rewarding source of biologically active natural products, while diterpenoids from fungi, such as the cyathane-type diterpenoids from and sp., the fusicoccane-type diterpenoids from and sp., the guanacastane-type diterpenoids from and sp.

Immunosuppressive Sesquiterpenoids from the Edible Mushroom .

The aim of this work was to comprehensively understand the chemical constituents of the edible mushroom and their bioactivity. A chemical investigation on this mushroom led to the isolation of 23 sesquiterpenoids including eighteen previously undescribed bergamotane sesquiterpenes, craterodoratins A-R (-), and one new victoxinine derivative, craterodoratin S (). The new structures were elucidated by detailed interpretation of spectrometric data, theoretical nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations, and single-crystal X-ray crystallographic analysis.

Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015-2020).

Fungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world.

Chemical constituents and their biological activities from the mushroom Pyropolyporus fomentarius.

The chemical constituents and their biological activities of the mushroom Pyropolyporus fomentarius were investigated in this study. Two previously undescribed pentacyclic lupane-type triterpenes, 3-formyloxybetulin and 3-formyloxybetulinic acid, two rare degraded ergosterols, pyropolincisterols A and B, along with ten known triterpenoids and four known ergosterols were isolated from the fruiting bodies of P. fomentarius.

Melodinines Y-Y, four monoterpene indole alkaloids from .

Melodinines Y-Y (1-4), four undescribed alkaloids were isolated from . Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine-leuconoxine combination.

Illudane Sesquiterpenoids from Edible Mushroom and Their Bioactivities.

To comprehensively understand the chemical constituents of the edible mushroom and their biological functions, a phytochemical separation of the cultural broth of led to the isolation of four new illudane sesquiterpenoids, agrocybins H-K (-), along with 10 known analogues (-). Compounds - were racemates of which and were further separated into single enantiomers as / and /. All new structures with absolute configurations were elucidated on the basis of an extensive spectroscopic analysis and quantum chemistry calculations.

Trichothecrotocins D-L, Antifungal Agents from a Potato-Associated .

Seven new merosesquiterpenoids, trichothecrotocins D-J (-), two new trichothecene sesquiterpenoids, trichothecrotocins K () and L (), and six known compounds (-, , and ), were isolated from a potato-associated fungus, . Compounds and were racemates which were further separated as pure enantiomers. Structures together with absolute configurations were established by extensive spectroscopic analysis, as well as quantum chemistry calculations on ECD and optical rotations.

Chemical constituents and their cytotoxicities from mushroom Tricholoma imbricatum.

Two undescribed triterpenes, tricholimbrins A and B, three undescribed steroids, tricholimbrins C‒E, one undescribed 4-chromanone derivative, along with 27 known compounds were isolated from fruiting bodies of the mushroom Tricholoma imbricatum. Tricholimbrins A and B are two polycyclic triterpenoids with a carbon degradation, while tricholimbrin C is a ring-rearranged steroid containing an aromatic moiety that might be derived from an ergosterol. Isocyathisterol, 3β,15α-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-trien-7-one, demethylincisterol A, and volemolide showed cytotoxicities to six human cancer cell lines.

Monoterpenoid indole alkaloids from the bark of Melodinus henryi.

Four new alkaloids, melodinines W-W (1-4), together with twenty one known alkaloids (5-25) were isolated from Melodinus henryi. The structures with absolute configurations were elucidated by extensive MS and NMR spectroscopic methods, as well as the single crystal X-ray diffraction and ECD calculations. All compounds were evaluated for their cytotoxicities to five human cancer cell lines.