STUDIES ON TRANSMISSIBLE LYMPHOID LEUCEMIA OF MICE.

Lymphoid leucemia of the mouse is readily transmitted by intravenous inoculations. The majority of the mice inoculated successfully develop leucemic, a smaller number of them, aleucemic lymphadenosis. The data presented favor the view that leucemic and aleucemic lymphadenosis are essentially the same condition.

TRANSMISSION EXPERIMENTS WITH LEUCOSIS OF FOWLS.

It is shown, in a carefully controlled experiment, that fowl leucemia can be readily transmitted from chicken to chicken by injection. Of 25 fowls, 13 were injected intravenously with blood from a chicken (No. 575) with erythroleucosis and 12 with blood from a chicken (No.

OBSERVATIONS WITH A NEW TRANSMISSIBLE STRAIN OF THE LEUCOSIS (LEUCEMIA) OF FOWLS.

Myeloid leucosis and erythroleucosis can be transmitted from one bird to others by emulsions of infiltrated organs, whole blood cells, and plasma. Inoculation is more often successful with blood cells or with whole blood than with plasma or with emulsions of organs infiltrated as the result of leucosis. Inoculation with material from a bird with myeloid or with erythroleucosis produces both myeloid and erythroleucosis, and in many instances mixed forms with characters of both.

STUDIES ON THE PRECIPITABLE SUBSTANCES OF BACILLI OF THE SALMONELLA GROUP.

Specific precipitable substances rich in carbohydrates, containing very little protein and small amounts of a material apparently of fatty nature, have been prepared from the main serological types of the typhoid-paratyphoid groups. The preparations in their present state of purity do not exhibit very pronounced chemical differences in spite of serological dissimilarity. In this respect the results differ from those observed with the polysaccharides of pneumococci.

ON PRECIPITABLE SUBSTANCES DERIVED FROM BACILLUS TYPHOSUS AND BACILLUS PARATYPHOSUS B.

Attempts to confirm certain statements that ether-soluble specific substances can be obtained from B. typhosus have lead to negative results. Two serologically active protein substances and another that was non-protein have been separated from B.

ANAPHYLACTIC SHOCK CAUSED BY ANTIBODY IN ANIMALS SENSITIZED BY ANTIGEN-REVERSED PASSIVE ANAPHYLAXIS.

Anaphylactic shock occurs (in rabbits) when the usual procedure for the production of passive anaphylaxis is reversed; that is, when an animal previously treated with antigen receives the corresponding antiserum by way of the circulating blood. This susceptibility to the action of anti-horse serum produced by injection of antigen reaches maximum intensity after an interval of 4 hours presumably required to permit penetration of the antigen in sufficient concentration into the tissues. Desensitization to the action of a shock-producing dose of anti-horse serum can be brought about by repeated small doses of the same antiserum.