[The clinical picture of lactate acidosis. 5. Lactatemia without acidosis. Conclusions].

Several inherited metabolic diseases are accompanied by a greater or lesser increase in blood lactate concentration under certain metabolic conditions. These diseases are glycogenosis type I (glocuse-6-phosphate deficiency), fructose-1,6-diphosphatase deficiency, glucose-induced hyperlactate emia, idiopathic lactate acidosis. The conditions are discussed when hyperlactate emia develops.

[Clinical picture of lactate acidosis. 4: Clinical significance of lactate acidosis].

The diagnosis of lactate acidosis is complicated by the fact that lactate determination is not a routine method in clinical chemistry. In fact, lactate analysis is performed only in special laboratories. Even in greater clinics this method is not routinely performed in differential diagnosis of acidotic states.

[The disease entity of lactate acidosis. 3. Lactate as a metabolic product].

High blood lactate concentrations can be achieved by means of intravenous bicarbonate infusion. Metabolic production of lactic acid in this case is a compensation mechanism for the alcalosis induced by bicarbonate. This metabolic condition is called lactate alcalosis.

[Methods and quality of information from myocardial scintigrams in the diagnosis of myocardial infarct].

There is an increasing importance of scintigraphy for the assessment of microcirculation in the myocardium. In animal experiments advantages and disadvantages of negative and positive representation of ischemic myocardiac areas were tried, after experimental infarction in particular. The results by computer scintigraphy prove that positive representation reveals an information on site and extent of an infarction.

[Blood picture in lactate acidosis. Part 2: acid-base equilibrium and lactate].

A differentiation between lactate emia (lactic acid emia) and lactate acidosis (lactic acidosis) is made. The normal value for blood lactate concentration is 1-2 mmol/1. The term lactate emia is used for lactate values between 2-6 mmol/1.

[The clinical picture of lactate acidosis. 1 : Lactate metabolism].

The definition of lactate acidosis (lactic acidosis) is discussed. The metabolism of lactate and pyruvate are described. An increase in lactate concentration should be called lactic acidemia (lactate emia).

[Effect of plant gums (swelling materials) on intestinal absorption in experimental animals].

The influence of various gums on the intestinal absorption of glucose and maltose was investigated in the experimental animal. The alterations in the concentrations of sodium and potassium were determined additionally. The following gums were used: alginate (sodium, potassium, calcium salts), Carrageenan, guaran, methylcellulose, carboxymethylcellulose.

[Effect of various dietary carbohydrates on supplementary cholesterol].

The effect of addition of different carbohydrates (starch, glucose, fructose) to the feed was investigated using the experimental animal. Additionally, the admixture of cholesterol and of cholesterol plus cholic acid was tested. Fructose (70% of the feed) causes a slight increase in serum triglyceride concentration and a very slight increase in triglyceride concentration in the liver.

[The use of stroma-free hemoglobin solutions as blood substitute].

Solutions of stroma free human hemoglobin and of polymerized hemoglobin were used for perfusion of isolated organs of the experimental animal (Wistar rats). Both preparations proved to be suited for maintainance of sufficient oxygen transport. Following intravenous infusion of greater amounts of hemoglobin or polymerized hemoglobin in the experimental animals (3.

[Use of xylitol as sugar substitute in diabetic children].

In 24 diabetic children treated with insulin xylitol was used as a sugar substitute for four weeks in an amount of 30 gms/day. In one case only the xylitol application was terminated before the end of the dietetic period because of diarrhoea. The other children tolerated xylitol fairly well, three of the children found the polyol too sweet.