Linked Th17 and Calgranulin Responses in Maternal-cord Blood Dyads of Preterm Gestations with Histologic Chorioamnionitis.

Introduction: Maternal-fetal immune crosstalk mechanisms are increasingly identified in the pathogenesis of gestational disorders, including histologic chorioamnionitis (HCA). Although an inflammatory Th17 immune phenotype has been described in preterm neonates with HCA, the associated maternal Th17 response is relatively unknown. To refine our understanding of Th17 biology in this context, we examined Th17 responses in maternal-cord blood dyads of preterm gestations.

Elevated neutrophil-lymphocyte ratios in extremely preterm neonates with histologic chorioamnionitis.

Objective: Histologic chorioamnionitis (HCA) is a placental inflammation linked to preterm birth and adverse neonatal outcome. The neutrophil-lymphocyte ratio (NLR) can identify various inflammatory disorders, however its utility in HCA is not clear. Our goal was to examine NLR values and HCA diagnoses in at-risk pregnancies and neonates.

Growing Up Fast: Managing Autism Spectrum Disorder and Precocious Puberty.

Case: John is a 4-year-old boy with autism spectrum disorder (ASD) and developmental delay who presented with concerns about increasing aggressive behavior at a follow-up visit with his developmental-behavioral pediatrician. Diagnosis of ASD was made via Diagnostic and Statistical Manual of Mental Disorders, 5th version criteria at initial evaluation at 34 months. Medical history at that time was pertinent for rapid linear growth since the age of 1 and recent pubic hair growth and penile enlargement.

Medical examinations and appeals for NJ public service workers.

The state of New Jersey has more than 200,000 employees in merit system jobs, who are covered by the Department of Personnel's formal hiring mechanism, including a medical examination and appeals process in which physicians play an important role. The State Medical Examiners Panel provides an innovative and practical approach to supply the Merit System Board with independent and objective findings and medical recommendations regarding the appeals. This article summarizes this process and discusses the structure, functions, and outcomes of the medical examiners Panel.

Sexual potency: a pioneer's thirty-five-year overview.

Thirty-five years of interest in human sexual potency are summarized, citing my clinical research and periodic publications during those decades. Emergence of scientific study of human sexuality has been rapid in recent years, leading to improved diagnostic and therapeutic techniques to benefit the impotent male. Although my approach pertained primarily to psychogenic etiology, the interdigitation of emotional and organic factors is emphasized.

Sexual potency before and after radical prostatectomy.

A TRIAD OF FACTORS CAN FAVORABLY INFLUENCE THE MAINTENANCE OF SEXUAL POTENCY AFTER RADICAL PROSTATECTOMY: the surgical avoidance of cavernous neurovascular bundles, the preoperative interest of the surgeon in broaching the subject with the patient and the continued encouragement given the patient by his attending physician as to probable preservation of sexual competency following the surgical procedure.

Sexual impotency: counseling of 388 private patients by urologist from 1954 to 1982.

Counseling toward restoration of sexual potency was provided in twenty-eight years to 388 impotent men by one urologist. Most were in the fifty to fifty-nine-year age group. Many had histories of serious trauma, major surgical procedures, vascular diseases, diabetes mellitus, and alcoholism.

Concurrent bilateral hypernephroma. Successful diagnosis and treatment of one patient.

Clinically unsuspected, bilateral concurrent clear cell cancers of each kidney were identified in a patient during evaluation for acute pancreatitis. A right renal lesion was demonstrated by computerized axial tomography (CAT) scan. Promptly thereafter percutaneous transfemoral aortography was performed, identifying separate, bilateral kidney neoplasms.

Urology/sexuality clinic: results of counseling of 67 men.

Of 67 psychogenically impotent men encountered in a new Urology/Sexuality Clinic during its first 36 months of operation at the University of California Medical Center in San Francisco, 52 returned for more than one urologic counseling visit, rendered individually by the senior author in all cases. There was a 79 percent success rate in the form of reinstatement of sexual activity, generally within three sessions, at weekly intervals. Success appeared, for the most part, unrelated to age, to previous treatment elsewhere, or even to major medical or surgical problems among some of these men who ranged in age from 18 to 78 years.

Sexual potency after radical prostatectomy.

Systematically acquired data on preservation or loss of sexual potency after radical prostatectomy have not been reported frequently. Our retrospective study is based on a review of the hospital records of 62 patients who underwent radical prostatectomy between 1968 and 1978. No notation as to preoperative potency was found in the records of 74 per cent of the patients.

Sexual impotency: current knowledge and treatment I. Urology/sexuality clinic.

Investigative and therapeutic measures for evaluating sexual impotency are rather recent. Psychogenic and organic problems may overlap. Thorough clinical appraisal and objective tests are currently affording better differentiation of etiology and, consequently, appropriate treatment.

Psychosexual problems of aging males: urologist's viewpoint.

Sexual impotency is commonly psychogenic. Any therapist who will take the time to hear out his patient's complaints can readily differentiate etiologies that are likely to respond to simple encouragement and support from those that would require more sophisticated psychology. Key points in the patient's medical history are identified to establish the diagnosis of psychogenic impotency.

Genitourinary disorders of old age: therapeutic considerations including counseling for sexual dysfunction.

Genitourinary tissues undergo physical changes with advancing age, due partly to hormonal alterations. However, the greatest influence on continuing sexual function during aging is emotional and is directly related to the psychologic history of the individual patient. The interested professional can help his patient substantially by simply taking time to listen, a process which permits identification of any psychogenic basis for the sexual dysfunction.

Encouraging preservation of sexual function postprostatectomy.

Sexual function after prostatectomy, particularly perirenal, has been reviewed in 128 patients treated in private practice for the past twenty years by one urologist with an avowed bias to encouraging postoperative sexual function. Surgical procedures for benign and neoplastic lesions of the prostate usually do not impair sexual potency when a patient is interested in coitus, has an available partner, and is encouraged by his physician. Review of the literature justifies encouraging preservation of sexual function postprostatectomy.