In Silico Prediction of Alkaline Phosphatase Interaction with the Natural Inhibitory 5-Azaindoles Guitarrin C and D.

The natural 5-azaindoles, marine sponge guitarrin C and D, were observed to exert inhibitory activity against a highly active alkaline phosphatase (ALP) CmAP of the PhoA family from the marine bacterium , with IC values of 8.5 and 110 µM, respectively. The superimposition of CmAP complexes with -nitrophenyl phosphate (NPP), a commonly used chromogenic aryl substrate for ALP, and the inhibitory guitarrins C, D, and the non-inhibitory guitarrins A, B, and E revealed that the presence of a carboxyl group at C6 together with a hydroxyl group at C8 is a prerequisite for the inhibitory effect of 5-azaindoles on ALP activity.

Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus.

Objective: Aim: To conduct a comparative analysis of the effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients with COVID-19 with concomitant type 2 diabetes.

Patients And Methods: Materials and Methods: There were examined 60 patients with COVID-19 with concomitant T2DM. Upon admission into the hospital and again after 10 days, serum levels of interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and capillaroscopy of the nail plate was performed.

Lyme borreliosis in Ivano-Frankivsk district, Ukraine: a epidemiological and clinical characteristics (2000-2022).

Objective: Aim: To give epidemiological and clinical characteristics of the morbidity of Lyme borreliosis in Ivano-Frankivsk region for the period of 2000-2022 years.

Patients And Methods: Materials and Methods: There were used annual reports (form №1) from the State Institution "Ivano-Frankivsk Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine" and 200 of "Medical records of inpatients" (form 003/о) of the Ivano-Frankivsk Regional Clinical Infectious Diseases Hospital for 2000-2022 years.

Results: Results: The morbidity of Lyme borreliosis in the Ivano-Frankivsk region has been permanently increasing since 2000.

Stonikacidin A, an Antimicrobial 4-Bromopyrrole Alkaloid Containing L-Idonic Acid Core from the Northwestern Pacific Marine Sponge .

Stonikacidin A (), the first representative of a new class of 4-bromopyrrole alkaloids containing an aldonic acid core, was isolated from the marine sponge . The compound is named in honor of Prof. Valentin A.

Squeezed light from an oscillator measured at the rate of oscillation.

Sufficiently fast continuous measurements of the position of an oscillator approach measurements projective on position eigenstates. We evidence the transition into the projective regime for a spin oscillator within an ensemble of 2 × 10 room-temperature atoms by observing correlations between the quadratures of the meter light field. These correlations squeeze the fluctuations of one light quadrature below the vacuum level.

Dissipative three-dimensional topological optical solitons with crossed localization of polarization components.

We present a new, to the best of our knowledge, type of vector three-dimensional dissipative optical solitons with more extended degrees of freedom in a laser or laser medium with saturable absorption. These solitons are reconfigurable, include polarization singularities, and have various mutual orientations of nearly toroidal localization domains of polarization components. Numerical modeling confirms the stability of these solitons and breathers and reveals their symmetry and even "supersymmetry," as well as transformations when parameters leave the stability region.

Clinical and echocardiographic findings in patients with COVID-19 across different severity levels.

Cardiovascular pathology can complicate the course of COVID-19. The study aimed to identify echocardiographic abnormalities and key prognostic factors influencing severe and fatal COVID-19 outcomes. This retrospective cohort study included clinical and echocardiogram data from 194 medical records of hospitalized patients with COVID-19: 100 moderate cases, 34 severe cases with favorable outcomes, and 60 severe cases with fatal outcomes.

[Prevention and treatment of venous thromboembolic complications in orthopedic patients].

Objective: To analyze the comprehensive program for prevention of thromboembolic complications in orthopedic patients.

Material And Methods: We have analyzed thromboembolic complications in orthopedic patients after surgeries on large joints over the past 5 years (2018-2022).

Conclusion: A comprehensive approach to prevention and treatment of thromboembolic complications including ultrasound, early surgical prevention of pulmonary embolism can significantly improve postoperative outcomes after joint replacement surgery.

Solutocapillary transport of oxygen bubbles in a diffusion-bubbling membrane core.

Bubbles are extensively explored as gas and energy carriers. However, despite notable progress, the bubble transport mechanisms are still poorly understood. At the present time there is not sufficient understanding of whether the body or surface forces play a major role in bubble transport in liquid interfacial systems.

Early-life maternal deprivation in rats increases sensitivity to the subsequent stressors: a pilot study.

Early life experiences, particularly maternal deprivation (MD), have long-lasting implications on emotional and cognitive development. Using Wistar rats as a model, this study explores the impact of MD followed by predator stress exposure (PSS) to simulate aspects of post-traumatic stress disorder (PTSD). A cohort of 41 male rat pups underwent MD from postnatal days 2 to 14, followed by PSS at day 90.

Prediction-Retrodiction Measurements for Teleportation and Conditional State Transfer.

Regular measurements allow predicting the future and retrodicting the past of quantum systems. Time-nonlocal measurements can leave the future and the past uncertain, yet establish a relation between them. We show that continuous time-nonlocal measurements can be used to transfer a quantum state via teleportation or direct transmission.

INFLUENCE OF BAD HABITS ON THE DEVELOPMENT OF ACQUIRED DEFORMATIONS IN THE MAXILLOFACIAL AREA.

Objective: The aim: Identifying the relationship between the presence of oral habit and acquired maxillomandibular anomalies, influence of oral habits on the skeleton and muscular system formation in children.

Patients And Methods: Materials and methods: We conducted clinical, radiological methods of examination of 60 patients aged 9-12 with acquired maxillomandibular anomalies, 15 persons aged 9-12 years without maxillomandibular anomalies and acquired deformities (norm group) and 15 persons aged 9-12 years with hereditary syndromes, which are combined with bone deformities in the maxillofacial area (comparison group).

Results: Results: Clinical examination showed that oral habits were manifested in 98.

Frequency locking and alternation of topological indices of vortex laser solitons.

We analyze the effect of frequency locking for polarization components of a semiconductor laser with fast gain, saturating absorption, and weak anisotropy. A mode of alternation of topological indices when leaving the locking area was found.

The Study of Radius End Mills with TiB Coating When Milling a Nickel Alloy.

Nickel alloy high-speed processing technology using ball-end mills is characterized by high contact temperature and leads to accelerated tool wear. One of the effective ways to increase its reliability and service life is to modify the surface by applying functional antifriction layers in addition to wear-resistant coatings. Diamond-like carbon is often used as the latter.

Computational F NMR of trifluoromethyl derivatives of alkenes, pyrimidines, and indenes.

The F NMR chemical shifts of 13 trifluoromethyl derivatives of alkenes, pyrimidines, and indenes were calculated at the DFT level using the BhandHLYP, BHandH, PBE, PBE0, O3LYP, B3LYP, KT2, and KT3 functionals in combination with the pcS-2 basis set. Best result was documented for the BHandHLYP functional: The mean absolute error (MAE) of 0.66 ppm for the scaled values was achieved for the range of about 20 ppm.

Investigation of the Information Possibilities of the Parameters of Vibroacoustic Signals Accompanying the Processing of Materials by Concentrated Energy Flows.

Creating systems for monitoring technology processes based on concentrated energy flows is an urgent and challenging task for automated production. Similar processes accompany such processing technologies: intensive thermal energy transfer to the substance, heating, development of the melting and evaporation or sublimation, ionization, and expansion of the released substance. It is accompanied by structural and phase rearrangements, local changes in volumes, chemical reactions that cause perturbations of the elastic medium, and the propagation of longitudinal and transverse waves in a wide frequency range.

Computational NMR of carbohydrates: 1. Glucopyranoses.

A high-level calculation of H and C NMR chemical shifts of α- and β-d-glucopyranoses is carried out at the DFT level with taking into account their conformational composition to reveal the most effective computational protocols. A number of dedicated DFT functionals in combination with Jensen's pcS-n (n = 0-4) family of basis sets were applied to evaluate the most reliable combination. It was found that BHandHLYP/pcS-2 provided the most accurate and reliable computational protocol.

May Measurement Month 2017-2019: an analysis of blood pressure screening results from Ukraine.

Hypertension is a key cardiovascular disease risk factor leading to premature mortality worldwide. The purpose of the May Measurement Month (MMM) campaign in Ukraine is to improve awareness of hypertension at the individual and population level. Adults (≥18 years) were screened at sites in Ukraine.

Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.

We studied the effect of molecular hydrogen (H) on the content of 2,3-diphosphoglyceric acid (2,3-DPG), ATP, malondialdehyde, and catalase activity in erythrocytes in chronic heart failure. Inhalation of 2% molecular hydrogen H was carried out for 40 min repeatedly (5 days) or once. Inhalation of H caused an increase in ATP concentration in both research groups, but was more pronounced after repeated inhalation.

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.

Molecular hydrogen (H) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical trial was conducted with 20 patients referring to the Specialized Cardiosurgical Clinical Hospital, Nizhny Novgorod, Russian Federation, who underwent elective surgery with CPB.

Risk Factors and Mechanisms of Cardiovascular Diseases in Posttraumatic Stress Disorder Model in Wistar Rats as Dependent on Stress Resistance and Age.

The article focuses on the pathogenetic mechanisms of posttraumatic stress disorder (PTSD), which is associated with psychological stress because of the coronavirus pandemic. The molecular mechanisms responsible for disease susceptibility in some individuals and stress resistance in others are amongst crucial research interests of experimental and clinical medicine. Priority data were obtained to indicate that distortions of synthesis and metabolism and, most significantly, a switch between two energy transport forms, glucose and lipids, underlie myocardial dysfunction in young and old stress-sensitive Wistar rats in a PTSD model.

1--Alkylglycerol Ethers from the Marine Sponge and Their Cytotoxic Activity.

The cytotoxicity-bioassay-guided fractionation of the ethanol extract from the marine sponge , whose 1--alkyl--glycerol ethers (AGEs) have not been investigated so far, led to the isolation of a complex lipid fraction containing, along with previously known compounds, six new lipids of the AGE type. The composition of the AGE fraction as well as the structures of 6 new and 22 previously known compounds were established using H and C NMR, GC/MS, and chemical conversion methods. The new AGEs were identified as: 1--(Z-docos-15-enyl)--glycerol (), 1--(Z-docos-17-enyl)--glycerol (), 1--(Z-tricos-15-enyl)--glycerol (), 1--(Z-tricos-16-enyl)--glycerol (), 1--(Z-tricos-17-enyl)--glycerol (), and 1--(Z-tetracos-15-enyl)--glycerol ().

Hierarchical tensile structures with ultralow mechanical dissipation.

Structural hierarchy is found in myriad biological systems and has improved man-made structures ranging from the Eiffel tower to optical cavities. In mechanical resonators whose rigidity is provided by static tension, structural hierarchy can reduce the dissipation of the fundamental mode to ultralow levels due to an unconventional form of soft clamping. Here, we apply hierarchical design to silicon nitride nanomechanical resonators and realize binary tree-shaped resonators with room temperature quality factors as high as 7.

Fluorine spin-spin coupling constants of pentafluorobenzene revisited at the ab initio correlated levels.

All possible spin-spin coupling constants, F- F, F- C, and F- H, of pentafluorobenzene were calculated at five different levels of theory, HF, DFT, SOPPA (CCSD), CCSD, and the SOPPA (CCSD)-based composite scheme with taking into account solvent, vibrational, relativistic, and correlation corrections. Most corrections were next to negligible for the long-range couplings but quite essential for the one-bond carbon-fluorine coupling constants. Hartree-Fock calculations were found to be entirely unreliable, while DFT results were comparable in accuracy with the data obtained using the wave function-based methods.