Overcoming barriers to opioid-induced constipation management in cancer patients.

Purpose: Opioid-induced constipation (OIC) is a common adverse effect of opioid therapy. We aim to identify the main barriers hindering clinical recommendations implementation and propose consensus solutions to improve OIC control in cancer patients.

Methods: Following collaborative and prioritization techniques, a scientific committee generated statements addressing possible barriers to optimal OIC management (related to patients, health providers and health care system), and potential interventions to overcome these barriers.

Tri- and dipeptides identification in whey protein and porcine liver protein hydrolysates by fast LC-MS/MS neutral loss screening and de novo sequencing.

We describe a fast (5 min) liquid chromatography tandem mass spectrometry method (LC-MS/MS) based on a 46 Da neutral loss of formic acid (H O and CO) to identify tri- and dipeptides (DIPEP) in whey protein and porcine liver protein hydrolysates and confirmed by further de novo sequencing. Sample solutions were acidified to favor [dipep + H] ions, and a m/z range of 50-300 was used to improve sensitivity. All dipeptide candidates were selected based on all possibilities of the 20 amino acid combinations, and their collision-induced dissociation fragments were screened via de novo sequencing.

Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues.

Baboon syndrome was first described as a particular type of systemic contact dermatitis, characterized by an exanthem with involvement of the buttocks and flexures. In children, it is an important entity to take into account for the differential diagnosis of viral exanthem. A large number of allergens have been implicated, although inhalation of mercury vapor is a common trigger.

Effect of prophylactic, low dose cephalexin on fecal and vaginal bacteria.

Effective prophylactic antimicrobial therapy for recurrent urinary tract infections depends upon the creation of minimal antimicrobial resistance in the fecal and vaginal flora. Cephalexin is known to be useful for prophylaxis clinically but substantial resistance has been reported in vaginal and rectal Escherichia coli at doses of 2 gm. per day.