Gastrointestinal cancer educational case series: management of metastatic adenocarcinoma of unknown primary origin in a Ph+ ALL survivor.

Introduction: Secondary malignancies and chronic end-organ sequelae are significant and steadily rising consequences of cancer therapy. The workup and management of a carcinoma of unknown primary must consider the patient's clinical presentation, radiologic and pathologic findings, and comorbidities.

Case Report: We present the case of a 50-year-old female survivor of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with significant treatment-related end-organ sequelae who developed a metastatic adenocarcinoma of unknown primary 15 years following curative therapy for her ALL.

Reduction of benzophenones with SmI2. Post electron transfer processes.

The kinetics of the reaction of several substituted benzophenones with SmI(2) in THF was studied by using stopped flow spectrometry. The electron transfer takes place during the dead time of mixing and for most derivatives it is nearly quantitative. In the presence of an excess of substrate and in the absence of proton donors the dimerization reaction to pinacol is second order in the radical anion and has a negative order in SmI(2).

Quantifying the electrostatic driving force behind SmI2 reductions.

The equilibrium constant for the electron transfer between SmI2 and substituted benzophenones was determined. The electron transfer reactions are exothermic with DeltaG(eq) ranging from -5.1 to -1.

On the role of samarium/HMPA in the post electron-transfer steps in SmI2 reductions.

The reaction of p,p'-dichlorobenzophenone with SmI2 was studied in the presence of variable amounts of HMPA. The electron-transfer step takes place instantaneously. In the presence of excess substrate, the addition of HMPA retarded the rate of coupling to pinacol by a factor of 250.

Dynamics of a village--marketing strategies for a new millennium.

Successfully marketing a dental practice involves more than an ad in the yellow pages. Choosing a dentist is a decision based on emotion. Dentists who take steps to become involved in their communities and interact with people will reap the personal and professional rewards necessary for a successful practice.

The super practice: a marketing and professionalism hybrid.

The old standard dental practice of yesterday, with a stubborn dentist who thinks marketing and advertising (concepts key to retail establishment success) are "unethical" doesn't cut it anymore. The practical retail concepts discussed about in this article allow dentists to create a marketing and professionalism hybrid. Providing first-class, customer-service treatment is the underlying principle.

The dynamics of a village: marketing strategies for a new millennium.

Successful marketing of a dental practice involves more than a yellow pages ad. picking a dentist is an emotionally based decision. Dentists who take steps to become involved in their communities and interact with the people within them will reap the personal and professional rewards necessary for a successful practice.