Publications by authors named "FABRI Z"

The aims of the present study were to monitor the changes in gross chemical composition of individual dromedary camel milk over a 5-yr period, to provide reference values, and to determine the effect of genetic and nongenetic factors influencing camel milk composition under intensive management. A total of 1,528 lactating dromedary camels were included in the study. Animals were fed a constant diet and were milked twice a day in a herringbone parlor.

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A comparative evaluation was done of the condition of the hypophyseal-thyroid axis in those patients with unspecific pulmonary diseases having taken part in the elimination of the aftermath of the ChNPP accident in 1986-1988, as well as patients with no particular prior history and essentially healthy subjects. With the thyroxin content tending downwards, the main differences manifested themselves at the level of hypophyseal control. Provision of the organism with more active forms of hormones was found to be maintained in all the cases at the physiological level.

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A total of 417 patients with cerebral circulatory disorders were examined in two biogeochemical regions of the UkrainianCarpathian Mountains. The first one is a region with iodine insufficiency; the second one is a region where the people use table salt in excess. It has been established that iodine insufficiency and excessive iodine concentration in the body of man are risk factors of the development of cerebrovascular disease.

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[Thyroid homeostasis in animals with iodine deficiency].

Nauchnye Doki Vyss Shkoly Biol Nauki

April 1989

The content of total iodine, its hormonal and nonhormonal fractions as well the level of protein-bound iodine in blood and basic tissue targets in representatives of 4 classes of animals: Esox lucius L., Rana esculenta, Streptopelia decaocto Priv., Lepus europaeus Pall.

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The levels of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (RT3), thyroxine-binding capacity (TBC), a free thyroxine index (FT4I) and thyroid-stimulating hormone (TSH) were studied by a radioimmunoassay in the blood of healthy schoolchildren aged 14 to 17 with stage I-II of thyroid hyperplasia residing in a mountain region of the Transcarpathian area, the Ukrainian SSR, with noticeable environmental iodine deficiency. Similar studies were conducted in a lowland region with a sufficient iodine level. A decrease in the concentration of T4, T3, RT3 and FT4I and higher TBC and TSH values were established in the healthy schoolchildren from the mountain region as compared to corresponding values in the schoolchildren from the lowland region indicating a lower level of homeostasis of thyroid hormones in the mountain region.

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Experimental acute toxic hepatitis causes functional reconstruction of the thyroid gland accompanied by intensified levels of total iodine and its hormonal compounds in blood. In most of non-thyroid tissues a decrease in the total and hormonal iodine content is revealed, but in kidneys these indices are considerably higher. The level of the nonhormonal iodine compounds in blood and tissues under study does not essentially vary and only in the liver, heart and lungs the expressed lowering of inorganic iodides is observed.

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By the spectrophotometric method the age changes of total iodine content, its hormonal and non-hormonal compounds in rats and men tissues (muscles, liver, kidney, heart, lungs, brain, spleen and blood) have been studied. It was established that the total iodine content decreased at the expense of the protein-bound iodine concentration and also of the butyl-alcohol extractable iodine. The exchange of thyroid hormones intensity lowered.

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It is found that a short-term (5 and 20 min) thermal effect (45 degrees C) induces no essential changes in the functional activity of the thyroid gland in rats. The level of total and hormonal iodine in the most important tissues is unchanged or insignificantly increased. With an increase in the thermal load time (60 min) there occurs an inhibition of the hormonogenic function of the thyroid gland which is accompanied by a pronounced decrease in the content of thyrohormones in blood and tissues.

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Single short-term physical loading as swimming and race in the treadmill evoke in rats changes in the total iodine amount, intensify the hormonogenic function of thyroid gland with hormonal iodine enrichment of tissues and metabolism of thyroid hormones. All these processes become more intensive when the duration of loads increases and they become weaker during 80 min swimming. The short-term swimming evokes more intensive mobilization and redistribution of iodine reserve in rats than race.

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The functional state of the thyroid gland was studied in 160 patients with different forms of disturbed cerebral circulation. The observations included studies of the iodine content and its fractions in the blood serum and a scanning of the thyroid gland. The author established the significance of thyroid gland dysfunction in the pathogenesis of hypertensive disease and cerebro-vascular insufficiency.

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