Publications by authors named "F-Z Mokrane"
Criteria based on measurements of lesion diameter at CT have guided treatment with historical therapies due to the strong association between tumor size and survival. Clinical experience with immune checkpoint modulators shows that editing immune system function can be effective in various solid tumors. Equally, novel immune-related phenomena accompany this novel therapeutic paradigm.
View Article and Find Full Text PDFThe clinical deployment of artificial intelligence (AI) applications in medical imaging is perhaps the greatest challenge facing radiology in the next decade. One of the main obstacles to the incorporation of automated AI-based decision-making tools in medicine is the failure of models to generalize when deployed across institutions with heterogeneous populations and imaging protocols. The most well-understood pitfall in developing these AI models is overfitting, which has, in part, been overcome by optimizing training protocols.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effectiveness of CT and PET/CT imaging in predicting patient outcomes after nivolumab therapy in individuals with relapsed or refractory Hodgkin lymphoma, focusing on the early response evaluation after treatment.
- - Researchers analyzed data from 45 patients and found that both CT and PET/CT response classifications were significantly associated with overall survival, underscoring the prognostic value of early imaging.
- - A notable finding is that 44% of patients had their CT response categories reclassified when using PET, with many classified as having a complete metabolic response, leading to a very high 2-year survival rate for these patients.
Purpose: To determine the volume of extrapancreatic necrosis that predicts severe acute pancreatitis and to assess the reliability of this threshold in predicting severe acute pancreatitis compared with current scoring systems and C-reactive protein (CRP) levels.
Materials And Methods: This institutional review board-approved, HIPAA-compliant retrospective study included patients with acute pancreatitis who were examined with computed tomography (CT) 2-6 days after disease onset. Extrapancreatic necrosis volume, Balthazar score, and CT severity index (CTSI) were calculated.