Publications by authors named "F-Q Meng"

Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinson's disease; however, individuals with Parkinson's disease are often unaware of their genetic status since clinical testing is infrequently offered. As a result, genetic information is not incorporated into clinical care, and variant-targeted precision medicine trials struggle to enrol people with Parkinson's disease. Understanding the yield of genetic testing using an established gene panel in a large, geographically diverse North American population would help patients, clinicians, clinical researchers, laboratories and insurers better understand the importance of genetics in approaching Parkinson's disease.

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Article Synopsis
  • Researchers examined the microstructure of a mixed aqueous solution of KCl and K2SO4 using techniques like X-ray scattering, Raman spectroscopy, and molecular dynamics simulation.
  • Key findings revealed that increasing KCl concentration shifted the main peak of the pair distribution function to a larger distance, suggesting changes in interactions from water molecules to chloride ions.
  • The study concluded that a higher concentration of KCl disrupts the hydrogen bond network more than K2SO4, which explains why KCl is more soluble in water compared to K2SO4 at room temperature.
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Context: The elevated low-density-lipoprotein cholesterol (LDL-C) in menopausal women is associated with higher risks of cardiovascular diseases.

Objective: The aim of this study is to investigate the influence and mechanism by which high postmenopausal FSH levels affect lipid profiles.

Methods: The serum FSH and lipid levels were examined in 400 Chinese postmenopausal women.

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