Establishment and application of a high-performance liquid chromatography-mass spectrometry method for analysis of 15 bisphenols and halogenated phenols in tea.

Using high-performance liquid chromatography-mass spectrometry, fifteen bisphenols and halogenated phenols were simultaneously analyzed in tea for the first time in China. Response surface methodology was used to optimize sample preparation conditions based on QuEChERS. Finally, the limits of detection and the limits of quantification were 0.

Cavity-enhanced light-induced thermoelastic spectroscopy for trace-gas sensing.

We report a trace gas sensing technique of cavity-enhanced light-induced thermoelastic spectroscopy (CE-LITES) with a Fabry-Pérot (F-P) optical cavity and a high-quality-factor resonant quartz tuning fork (QTF). Pound-Drever-Hall (PDH) locking method is used to lock the laser to the optical cavity. With only a short 9-cm optical cavity (finesse, ∼1283) and a tiny commercially available standard QTF (Q-factor, ∼38910), a CE-LITES sensor for acetylene detection was developed to demonstrate this technique, achieving a minimum detection limit (MDL) of 7.

Fermented Palm Kernel Cake Improves the Rumen Microbiota and Metabolome of Beef Cattle.

In this study, we utilised palm kernel cake as a substrate and fermented it with a composite of bacteria ( CGMCC No. 27203 and CGMCC No. 27202) and enzymes.

The impact of bloodmeal and geographic region on the richness, diversity, and function of internal microbial community in from the Qinghai province, China.

Background: Ticks are ectoparasites that feed on blood and pose a threat to both the livestock industry and public health due to their ability to transmit pathogens through biting. However, the impact of factors such as bloodmeal and geographic regions on the bacterial microbiota of remains poorly understood.

Methods: In this study, we used the v3-v4 region of the 16S rRNA gene to sequence the microbiota of from eight groups (HY_M, YS_M, XH_M, LD_M, BM_M, LD_F_F, LD_F, and BM_F_F) in Qinghai Province.

Stability and chemical bonding in a series of inverse sandwich actinide boride clusters (AnB) with δ bonding.

An inverse sandwich structure has been computationally predicted for uranium boride and extended to the series of actinide elements (An) from Th to Cm. The electronic structure and chemical bonding of these novel compounds have been analyzed using density functional theory and multireference wave-function based methods. We report the trends in electronic structure and bonding for AnB, and found that (d-π)π and (d-p)δ are the most important factors in the stability of AnB.

Improved efficacy and safety of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) in China: a subgroup of ALPINE.

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has different epidemiology in Chinese vs. Western patients, but there are few studies of CLL/SLL in large populations of Chinese patients. ALPINE is a global phase 3 trial investigating Bruton tyrosine kinase inhibitors zanubrutinib vs.

Highly sensitive optical fiber pressure sensor based on the FPI and Vernier effect via femtosecond laser plane-by-plane writing technology.

In this paper, a highly sensitive pressure sensor based on fiber-optic Fabry-Perot interferometers (FPIs) and the Vernier effect (VE) is proposed and experimentally demonstrated. We employ a closed capillary-based for the sensing cavity, and an created through femtosecond laser refractive index modulation for the reference cavity, which remains impervious to pressure changes. Connecting these two FPIs in series produces a VE-based cascaded sensor with a clear spectral envelope.

Disparities in Visual Field Testing Frequency Among Subjects With Glaucoma.

Purpose: Prior evidence suggests racial disparities in the utilization of visual field testing (VFT) for the diagnosis and monitoring of glaucoma. In this study, we considered the effect of baseline glaucoma severity and socioeconomic disadvantage along with other potential confounders such as test reliability, ancillary tests, and glaucoma surgeries on racial disparity in the frequency of VFT.

Methods: The records of all subjects with a diagnosis of glaucoma who received VFT at an academic, tertiary care facility from January 2018 to December 2021 were accessed.

Study on Linewidth and Phase Noise Characteristics of a Narrow Linewidth External Cavity Diode Laser.

In the field of inter-satellite laser communication, achieving high-quality communication and compensating for the Doppler frequency shift caused by relative motion necessitate lasers with narrow linewidths, low phase noise, and the ability to achieve mode-hop-free tuning within a specific range. To this end, this paper investigates a novel external cavity diode laser (ECDL) with a frequency-selective F-P etalon structure, leveraging the external cavity F-P etalon structure in conjunction with an auxiliary filter to achieve single longitudinal mode selection. The laser undergoes linewidth testing using a delayed self-heterodyne beating method, followed by the testing of its phase noise and frequency noise characteristics using a noise analyzer, yielding beat spectra and noise power spectral density profiles.

A Novel Score Based on Controlled Attenuation Parameter Accurately Predicts Hepatic Steatosis in Individuals With Metabolic Dysfunction Associated Steatotic Liver Disease: A Derivation and Independent Validation Study.

Introduction: In metabolic dysfunction-associated steatotic liver disease, the diagnostic efficacy of controlled attenuation parameter (CAP) was not very accurate in evaluating liver fat content. The aim of this study was to develop a score, based on CAP and conventional clinical parameters, to improve the diagnostic performance of CAP regarding liver fat content.

Methods: A total of 373 participants from 2 independent Chinese cohorts were included and divided into derivation (n = 191), internal validation (n = 75), and external validation (n = 107) cohorts.

Water-blocking Asphyxia of N95 Medical Respirator During Hot Environment Work Tasks With Whole-body Enclosed Anti-bioaerosol Suit.

Background: During hot environment work tasks with whole-body enclosed anti-bioaerosol suit, the combined effect of heavy sweating and exhaled hot humid air may cause the N95 medical respirator to saturate with water/sweat (i.e., water-blocking).

AAV- partially corrects motor deficits and ALS/FTLD-related pathology in mice.

Loss of function of progranulin (PGRN), encoded by the () gene, is implicated in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are currently in clinical trials. However, it is difficult to test the efficacy of PGRN-enhancing drugs in mouse models due to the mild phenotypes of mice.

Structure-Guided Design and Synthesis of a Pyridazinone Series of Proteasome Inhibitors.

There is an urgent need for new treatments for Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143, a preclinical candidate for visceral leishmaniasis which acted through inhibition of the proteasome. A related analogue, active against , showed suboptimal efficacy in an animal model of Chagas disease, so alternative proteasome inhibitors were investigated.

An atlas of healthy and injured cell states and niches in the human kidney.

Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods. Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main cell types, which include rare and previously undescribed cell populations.

Toward Chiral Lasing from All-Solution-Processed Flexible Perovskite-Nanocrystal-Liquid-Crystal Membranes.

Circularly polarized (CP) coherent light sources are of great potential for various advanced optical applications spanning displays/imaging to data processing/encryption and quantum communication. Here, the first demonstration of CP amplified spontaneous emission (ASE)/lasing from a free-standing and flexible membrane device is reported. The membrane device consists of perovskite nanocrystals (PNCs) and cholesteric liquid crystals (CLCs) layers sandwiched within a Fabry-Pérot (F-P) cavity architecture.

Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway.

Ethnopharmacological Relevance: Echinacoside (ECH) is the dominant phenylethanoid glycoside-structured compound identified from our developed herbal formula Huangci granule, which has been previously reported to inhibit the invasion and metastasis of CRC and prolong patients' disease-free survival duration. Though ECH has inhibitory activity against aggressive colorectal cancer (CRC) cells, its anti-metastasis effect in vivo and the action mechanism is undetermined. Given that ECH has an extremely low bioavailability and gut microbiota drives the CRC progression, we hypothesized that ECH could inhibit metastatic CRC by targeting the gut microbiome.

No thick carbon dioxide atmosphere on the rocky exoplanet TRAPPIST-1 c.

Seven rocky planets orbit the nearby dwarf star TRAPPIST-1, providing a unique opportunity to search for atmospheres on small planets outside the Solar System. Thanks to the recent launch of the James Webb Space Telescope (JWST), possible atmospheric constituents such as carbon dioxide (CO) are now detectable. Recent JWST observations of the innermost planet TRAPPIST-1 b showed that it is most probably a bare rock without any CO in its atmosphere.

High-performance plasmonic polymer modulators through mode hybridization and electro-thermomechanical effects.

In this work, an electro-optical polymer modulator with double-layered gold nanostrips, a polymer nanograting, and a metal substrate is proposed and designed. Interestingly, mode hybridization between the Fabry-Pérot (F-P) and anti-bonding modes is formed, and strongly depends on the nanograting size, which can be controllably modulated by an injection current. The simulation and calculation results show that the temperature sensitivity and large structural sensitivity for the polymer modulator could remain constant during the current-tuning process, and a near-zero reflectance and a low linewidth of 13.

Probe type TFBG-excited SPR fiber sensor for simultaneous measurement of multiple ocean parameters assisted by CFBG.

The tilted fiber Bragg grating(TFBG), chirped fiber Bragg grating(CFBG), Vernier effect and metal surface plasmon resonance(SPR) effect are effectively combined to form a probe type fiber sensor for simultaneous measurement of seawater salinity, temperature and depth(STD). The SPR effect excited by the TFBG is achieved by covering a gold layer around the TFBG, which is used to measure the refractive index (RI) of seawater. The core mode of TFBG is used to detect the change of seawater temperature and the measurement of TFBG reflection spectrum is realized by inscribing a CFBG after the TFBG, which makes the sensor have a probe type design and more beneficial to practical applications.

Study of SO measurement based on a dual optical path Fabry-Perot correlation spectroscopy.

This paper investigates a method for measuring SO concentration using Fabry-Perot interferometer correlation spectroscopy. In this method, the experimental system is designed as a separated beam, with the beam entering the F-P cavity at two incidence angles simultaneously to match the peak and valley positions of the SO absorption cross-section. The system achieves a 2σ detection limit of 28.

Antioxidant Activity and Cell Protection of Glycosylated Products in Different Reducing Sugar Duck Liver Protein Systems.

Duck liver is an important by-product of duck food. In this study, we investigated the effects of glucose, fructose, and xylose on the antioxidant properties of glycosylated products of duck liver protein and their protective effects on HepG2 cells. The results show that the glycosylation products of the three duck liver proteins (DLP-G, DLP-F, and DLP-X) all exhibit strong antioxidant activity; among three groups, DLP-X shows the strongest ability to scavenge DPPH, ·OH free radicals, and ABTS free radicals.

Abnormal Conduction Zone Detected by Isochronal Late Activation Mapping Accurately Identifies the Potential Atrial Substrate and Predicts the Atrial Fibrillation Ablation Outcome After Pulmonary Vein Isolation.

Background: The presence of abnormal substrate of left atrium is a predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation. We aimed to investigate the isochronal late activation mapping to access the abnormal conduction velocity for predicting AF ablation outcome.

Methods: Forty-five paroxysmal AF patients (30 males, 57.