Publications by authors named "F van Rhee"
Tumor immune microenvironmental alterations occur early in multiple myeloma (MM) development. In this study, we aim to systematically characterize the tumor immune microenvironment (TME) and the tumor-immune interactions from precursor stages, i.e.
View Article and Find Full Text PDFIn our study of 246 newly diagnosed individuals with MGUS or SMM (115 MGUS, 131 SMM), we found that 19% reported anxiety, with no significant difference between the MGUS and SMM groups (22% vs. 17%). Those with a history of psychiatric disorders or belonging to certain racial groups were more likely to experience anxiety.
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- The Glasgow prognostic score (GPS) and CAR-HEMATOTOX (CAR-HT) score help identify multiple myeloma (MM) patients at risk for immune-related side effects and early death during cellular immunotherapy.
- A study involving 126 MM patients treated with T-cell redirecting bispecific antibodies (bsAb) assessed the impact of these scores on patient outcomes.
- While 19% of patients were deemed high risk according to GPS, they did not experience worse outcomes, but those classified as high risk by CAR-HT faced more infections and had lower survival rates, indicating the need for better infection management.
Article Synopsis
- * Dysgeusia was experienced by 15% of patients, while the average weight loss during treatment was around 6%, with weight loss lasting for about half of the patients even after stopping the treatment.
- * To help minimize these side effects, researchers suggest that longer intervals between doses may be beneficial, indicating a need for further studies on this approach in future clinical trials.