Publications by authors named "F van Landeghem"
Article Synopsis
- Intracerebral hemorrhage (ICH) is a severe type of stroke with a high mortality rate, leading to complications like increased intracranial pressure (ICP) and poor outcomes for patients.
- The body's natural responses to manage ICP can become overwhelmed after severe strokes, necessitating clinical interventions, among which hypertonic saline (HTS) is investigated as a potential treatment.
- In a study with rats experiencing ICH, HTS administration showed no significant improvement in edema, behavior, or brain cell health, suggesting that it does not provide benefits post-ICH.
Purpose: Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and subclonally expand under primary therapy.
Experimental Design: To identify candidate markers and to experimentally access dynamics of subclonal progression in glioblastoma, we established a discovery cohort of paired vital cell samples obtained before and after primary therapy.
Photoacoustic remote sensing (PARS) microscopy is an emerging label-free optical absorption imaging modality. PARS operates by capturing nanosecond-scale optical fluctuations produced by photoacoustic pressures. These time-domain (TD) variations are usually projected by amplitude to determine optical absorption magnitude.
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