Publications by authors named "F ud Din"
This study aims to develop a thermoresponsive biomaterial system of irinotecan (IRT) and curcumin (CUR) nano-transferosomal gel (IRT-CUR-NTG) for targeting colorectal cancer (CRC). The IRT-CUR-NTs were statistically optimized and loaded into poloxamer-based thermosensitive gel. Transmission electron microscopy (TEM), Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) of the IRT-CUR-NTs were performed, whereas pH, gelation time, gelation temperature, gel and mucoadhesive strength of the IRT-CUR-NTG were investigated.
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- Common genetic variation at the 11q23.1 locus is linked to colorectal cancer risk, complicating the understanding of its mechanisms due to complex gene interactions and expression patterns.
- The study utilizes various sequencing methods and mouse models to identify key genes, especially highlighting rs3087967 as a crucial variant that influences the expression of 21 genes associated with tuft cell markers.
- The findings suggest that the risk genotype at rs3087967 leads to a deficiency in tuft cells, which are important for tumor suppression, positioning these cells as protective elements in colorectal cancer development.
Article Synopsis
- Lynch syndrome (LS) patients have a high risk of colorectal cancer, currently monitored through biennial colonoscopy, which can be burdensome and invasive.
- This study assessed whether faecal immunochemical testing (FIT) for faecal haemoglobin could effectively replace the need for routine colonoscopy in LS surveillance.
- Results showed FIT has low sensitivity for detecting adenomas, with no improvement when a second test was added, suggesting it may not be a viable alternative to colonoscopy.
Article Synopsis
- Traumatic brain injury (TBI) leads to neurological deficits and oxidative stress, prompting research into the neuroprotective effects of Daidzein, a phytoestrogen.
- In vitro studies with HT-22 cells showed that Daidzein improved cell survival and reduced harmful nitric oxide production, while in vivo tests using three doses of Daidzein demonstrated significant improvements in neurological functions and anxiety behaviors.
- Molecular analysis indicated that Daidzein enhances antioxidant defenses and reduces markers of cell damage and apoptosis, showing promise as a treatment for TBI-related complications.
Article Synopsis
- The study evaluated the non-return rate of faecal immunochemical tests among patients referred for high-risk colorectal cancer symptoms, finding that 11.9% of 7345 patients did not submit their tests.
- Non-returners tended to be younger, predominantly male, and from lower socioeconomic backgrounds, and they exhibited different clinical outcomes compared to those who returned the test.
- Despite a higher prevalence of colorectal cancer in those who underwent investigations, the overall cancer prevalence was similar between returners and non-returners over a median follow-up of 25 months, indicating potential issues in care access or follow-up for non-returners.