Resilience in adversity: Exploring adaptive changes in cancer cells under stress.

Objective: Cancer cells undergo adaptive processes that favor their survival and proliferation when subjected to different types of cellular stress. These changes are linked to oncogenic processes such as genetic instability, tumor proliferation, therapy resistance, and invasion. Therefore, this study aimed to review studies that discuss possible morphological and genetic changes acquired by neoplastic cells under stressful conditions.

Potential of Lambda-Cyhalothrin for Controlling the Black Armyworm Spodoptera cosmioides (Walker) (Lepidoptera: Noctuidae): Toxicity and Midgut Histopathological Effects.

Caterpillars of the genus Spodoptera are the main pests in soybean and cotton crops and Spodoptera cosmioides causes more severe losses than other caterpillars in these agricultural crops. However, there are few recommended insecticides for controlling this pest. Lambda-cyhalothrin is a pyrethroid used to control a wide spectrum of arthropods including lepidopterans.

Heavy metal(loid)s and nutrients in sewage sludge in Portugal - Suitability for use in agricultural soils and assessment of potential risks.

The presence of heavy metal(loid)s in sewage sludge is a cause of concern and an obstacle to its agricultural valorisation. This study analysed the elemental composition of sewage sludge from 42 Portuguese wastewater treatment plants (WWTPs) during summer and winter, investigating heavy metal(loid) contamination, nutrient content, and potential risks related to sludge application to agricultural soils. Levels of 8 heavy metal(loid)s were investigated, ranging from not detected (Hg) to 5120 mg kg dw (Zn), decreasing in the order Zn > Cu > Cr > Ni > Pb > As>Cd > Hg.

Sacubitril-Valsartan in Cancer Therapy-Induced Heart Failure: A Systematic Review and Meta-Analysis of Functional and Hemodynamic Parameters.

Background: Cancer therapy-induced cardiotoxicity (CTRCD), in the form of heart failure with reduced ejection fraction (HFrEF), is being increasingly recognized. However, the potential benefits of sacubitril/valsartan (S/V) in managing HFrEF secondary to CTRCD remain unclear.

Objective: We performed a systematic review and meta-analysis to assess the effectiveness of S/V in preventing cardiotoxicity.

Exploring environmental risk in soils: Leveraging open data for non-sampling assessment?

Soil contamination by heavy metals (HM) is a critical area of research. Traditional methods involving sample collection and lab analysis are effective but costly and time-consuming. This study explores whether geostatistical analysis with GIS and open data can provide a faster, more precise, and cost-effective alternative for HM contamination assessment without extensive sampling.