A novel Ca double cone vector system to treat compromised skin.

Background: Stressed, damaged or very aged skin is predominantly characterized by a malfunctioning skin barrier. Underlying skin barrier malfunction is a reduced or defective calcium gradient in the epidermis. Consequently, replenishing the compromised skin's calcium stores with topical calcium could be a potential therapeutic approach.

Early Sensory Profile in Autism Spectrum Disorders Predicts Emotional and Behavioral Issues.

Background: Abnormal sensory reactivity is considered one of the diagnostic criteria for autism spectrum disorders (ASD) and has been associated with autism severity, poorer functional outcomes, and behavioral difficulties across the lifespan. Its early characterization could provide valuable insights into the processes favoring the instantiation of maladaptive behaviors. Objectives: The present study has two aims: (1) to describe the sensory profile of preschool children with ASD compared with an age-matched population of children with a diagnosis of language disorder (DLD) and typically developing (TD) control peers; (2) to explore within each group whether the sensory alterations play a predictive role in the instantiation of emotional and behavioral issues.

Youthful and age-related matreotypes predict drugs promoting longevity.

The identification and validation of drugs that promote health during aging ("geroprotectors") are key to the retardation or prevention of chronic age-related diseases. Here, we found that most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e.

Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications.

The cosmetic industry requires more and more expensive actives and ingredients such as retinol, coenzyme Q10, proteins, peptides and biotechnologically produced molecules. In this study, we demonstrate the development of a cost effective formulation of a nanostructured lipid carrier (NLC) or solid lipid nanoparticles (SLN) improving peptide delivery into skin. NLC or SLN are very suitable vehicles for the delivery of active ingredients into skin.

Length scales and dynamics in the reorientational relaxation of tracers in molecular and polymeric glass formers via electron spin resonance spectroscopy.

It is widely accepted that a temperature region exists above the glass transition temperature, playing a fundamental role in the physics of polymers and glass formers. In this region, several dynamic crossovers have been experimentally and numerically revealed in the past years and the onset of glassy behavior is generally located, because of cooperative and heterogeneous features exhibited by the dynamics. In this Article, the rotational dynamics of two different stiff molecular spin probes dissolved in poly(propylene glycol) has been investigated by electron spin resonance spectroscopy in a wide temperature range.