Publications by authors named "F Zulhendri"
Stroke is the world's second-leading cause of death. Current treatments for cerebral edema following intracerebral hemorrhage (ICH) mainly involve hyperosmolar fluids, but this approach is often inadequate. Propolis, known for its various beneficial properties, especially antioxidant and anti-inflammatory properties, could potentially act as an adjunctive therapy and help alleviate stroke-associated injuries.
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- Autophagy is a vital cellular process that helps maintain balance and remove damaged components, and its dysfunction is linked to diseases like cancer and metabolic syndromes.
- Studies suggest propolis, known for its antimicrobial and anti-inflammatory properties, may also influence autophagy, but this aspect hasn't been widely explored yet.
- This review aims to examine how propolis affects autophagy in biological models, which could lead to new propolis-based nutritional products and therapies.
Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to regulate lipid metabolism. A lower amount of BAT compared to WAT, along with adipose tissue dysfunction, can result in obesity. Studies have shown that selenium supplementation protects against adipocyte dysfunction, decreases WAT triglycerides, and increases BAT triiodothyronine (T).
View Article and Find Full Text PDFα-Mangostin (a xanthone derivative found in the pericarp of L.) and propolis extract (which is rich in flavonoids and phenols) are known for their antioxidant properties, making them potential supplements for the treatment of oxidative stress-related conditions. However, these two potential substances have the same primary drawback, which is low solubility in water.
View Article and Find Full Text PDFBackground: Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain affected by dementia processes.
Objective: This systematic review aims to elaborate on the involvement of the Hippo signaling pathway and autophagy in modulating the progression and severity of dementia in aging.