Publications by authors named "F Zucchi"
Waterhouse-Friderichsen Syndrome (WFS) is a rare but life-threatening condition characterized by massive adrenal hemorrhage. WFS represents one of the features of the Overwhelming Post-Splenectomy Infection, which occurs any time after spleen removal and is recognized as the most serious complication in asplenic patients. We report a fatal case of WFS resulting from Streptococcus pneumoniae infection in a vaccinated and splenectomized patient.
View Article and Find Full Text PDFIs CRPS-1 a Chronic Disabling Disease? A Long-term, Real-Life Study on Patients Treated With Neridronate.
Clin Med Insights Arthritis Musculoskelet Disord
November 2024
Article Synopsis
- - This study focused on assessing the long-term effects of neridronate treatment on patients with Complex Regional Pain Syndrome type 1 (CRPS-1), a condition that causes severe pain and disability, particularly in the upper limbs.
- - A retrospective analysis included 49 patients who received neridronate infusions, revealing that 93.9% of them experienced a complete resolution of symptoms after an average follow-up of about 4 years, with 77.6% showing no functional limitations.
- - Key factors influencing residual disability post-treatment were found to be younger age and the delay between the onset of the disease and the start of treatment, suggesting that earlier intervention may lead to better recovery outcomes.
Article Synopsis
- The study investigates serum levels of bone turnover markers and Wnt signaling in patients with complex regional pain syndrome type 1 (CRPS-1) before treatment.
- It compares bone turnover marker values (sclerostin, DKK1, CTX-I, P1NP) of 34 CRPS-1 patients with age and sex-matched healthy controls, finding significant differences for P1NP, sclerostin, and DKK1.
- Results suggest that early CRPS-1 is associated with increased bone formation markers and decreased levels of Wnt signaling inhibitors, indicating potential osteocyte dysfunction rather than increased osteoclast activity.
Unlabelled: In this study, we investigated how the COVID-19 pandemic involved osteoporosis care in patients treated with denosumab. Almost a third of patients missed the prescription renewal, mandatory to obtain the subsidized drug. Among patients who suspended denosumab, more than half reported fragility fractures.
View Article and Find Full Text PDFBackground: No data on the permanent and curative effect of bisphosphonate treatment in patients with complex regional pain syndrome type-1 (CRPS-1) are currently available. The aim of this pre-specified, open-label, observational study was to evaluate the long-term efficacy and safety of neridronate treatment.
Design: A pre-specified, open-label, extension study.