Publications by authors named "F Zani"
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation.
View Article and Find Full Text PDFPost-SARS-CoV-2 telogen effluvium has been described in case reports of COVID-19 patients. We evaluated the prevalence of post-SARS-CoV-2 telogen effluvium in patients from a single medical center, exploring any causal links with the infection. Our hospital-based, cross-sectional study was conducted with patient participants discharged with a diagnosis of SARS-CoV-2 pneumonia from 1 March to 4 April 2020.
View Article and Find Full Text PDFArticle Synopsis
- PI3Kγ, a member of the phosphatidylinositides-3 kinases family, plays a complex role in liver cancer (HCC) development, particularly in the context of obesity and insulin resistance.
- In studies with mice, removing PI3Kγ led to reduced tumor growth in cases of HCC associated with obesity, despite no apparent change in lean mice.
- The findings suggest that targeting PI3Kγ could offer a new strategy for treating or preventing obesity-related HCC by improving metabolic conditions and reducing inflammation.
Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology.
Front Immunol
October 2021
Article Synopsis
- Regulatory T cells (Tregs) are crucial for controlling inflammation and exist in almost all body tissues, playing both positive and negative roles depending on the context.
- Nutrient availability significantly affects Treg function, and Tregs heavily rely on fatty acid oxidation for their energy needs and fitness.
- The review examines key metabolic pathways in Tregs, particularly how local nutrient environments and gut microbial by-products influence their differentiation and stability.
Article Synopsis
- *Research shows that fructose alters how immune cells, specifically monocytes and macrophages, metabolize nutrients, enhancing their inflammatory responses.
- *In mice, fructose exposure boosts inflammatory cytokine levels during systemic inflammation, indicating that fructose may have harmful effects on immune function and metabolic flexibility.*