Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.

Estimation of TP53 mutations for endometrial cancer based on diffusion-weighted imaging deep learning and radiomics features.

Objectives: To construct a prediction model based on deep learning (DL) and radiomics features of diffusion weighted imaging (DWI), and clinical variables for evaluating TP53 mutations in endometrial cancer (EC).

Methods: DWI and clinical data from 155 EC patients were included in this study, consisting of 80 in the training set, 35 in the test set, and 40 in the external validation set. Radiomics features, convolutional neural network-based DL features, and clinical variables were analyzed.

Prediction Models for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.

Background: Stroke is one of the most serious illnesses worldwide and is the primary cause of acquired disability among adults. Post-stroke cognitive impairment (PSCI) is a complication of stroke that significantly impacts patients' daily activities and social functions. Therefore, developing a risk prediction model for PSCI is essential for identifying and preventing disease progression.

Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus.

This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women undergoing FET (discovery cohort: 38 HCs and 31 GDM; validation cohort: 85 HCs and 39 GDM). Gut microbial profiles of the discovery cohort were investigated during the pre-pregnancy (Pre), first trimester (T1), and second trimester (T2).

Effect of different restorative design and materials on stress distribution in cracked teeth: a finite element analysis study.

Objectives: To compare the stress distribution and crack propagation in cracked mandibular first molar restored with onlay, overlay, and two types of occlusal veneers using two different CAD/CAM materials by Finite Element Analysis (FEA).

Materials And Methods: A mandibular first molar was digitized using a micro CT scanning system in 2023. Three-dimensional dynamic scan data were transformed, and a 3D model of a cracked tooth was generated.