Publications by authors named "F Y Ng"
Introduction: Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial, meaning identification of effective treatments has been limited. The antifibrotic effect of the bile acid ursodeoxycholic acid (UDCA) is established in cases of liver fibrosis however its mechanism and role in cardiac fibrosis is less well understood.
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- * A systematic review will evaluate the impact of chatbot interventions on mental well-being in the Asian population, utilizing four electronic databases for data collection until December 2024.
- * The study will include randomized controlled trials available in English or Chinese, assess bias and evidence quality, and share findings through peer-reviewed journals, funded by Tung Wah College.
Background: Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI.
Methods: The Italian Genetic Study of Early-Onset Myocardial Infarction is a cohort study enrolling patients with MI before 45 years.
Genetic and phenotypic architecture of human myocardial trabeculation.
Nat Cardiovasc Res
December 2024
Article Synopsis
- Cardiac trabeculae are muscular structures in the heart that have a crucial but not fully understood role in heart function and disease.
- A study involving over 47,000 participants from the UK Biobank found links between trabecular shape and rare genetic variants in 56 genes related to heart muscle function and development.
- The research also revealed 68 genetic regions associated with heart condition pathways, indicating that variations in trabeculation may influence the severity of heart diseases like hypertrophic and dilated cardiomyopathy.