Presence of antibodies to the viral proteins in sera of mammals bearing RSV-induced tumours.

The sera of RSV tumour-bearing rats, hamsters and monkeys were tested for the presence of antibodies to RSV proteins. Complement fixation test and radioimmunoprecipitation followed by SDS-polyacrylamide gel electrophoresis were used for detection of antibodies to the products of the gag, env and src genes of RSV. Antibodies to the env and gag gene products were found in sera of tumour-bearing monkeys.

Characterization of tumors induced in adult Macaca mulata monkeys with Carr-Zilber strain of Rous sarcoma virus.

The Carr-Zilber strain of Rous sarcoma virus is highly oncogenic for adult monkeys of the species Macaca mulata. In the present study, we examined some characteristics of tumor growth when the tumor either regressed or progressed until it killed its host. We followed the kinetics of antibody formation to antigens coded by CZ-RSV in animals with a different course of tumor disease.