Publications by authors named "F Xavier Medina"
Article Synopsis
- The study focuses on understanding how IgG antibody levels against SARS-CoV-2 behave over time in a group of people from Puerto Rico, especially in relation to vaccination and prior infections.
- Researchers conducted a longitudinal analysis with participants providing regular samples for testing from June 2020 to August 2022, allowing them to assess how antibody levels changed based on factors like vaccination status and the timing of infections.
- Findings revealed that a significant majority of participants showed increased antibody prevalence by the end of the study, with vaccinations contributing substantially to IgG levels, while a third booster dose was effective in enhancing and prolonging antibody response.
Background: Serology for dengue viruses (DENV) and Zika virus (ZIKV) has been hindered by antibody cross-reactivity, which limits the utility of these tests for surveillance and assessment of sero-status. Our aim was to develop a multiplexed IgG-based assay with increased accuracy to assess the history of previous DENV and ZIKV infections.
Methods: We developed and assessed the analytical performance of a sample-sparing, multiplexed, microsphere-based serological assay using domain III of the envelope protein (EDIII) of DENV serotypes 1-4 and ZIKV, the most variable region between each virus.
Polyphenols are compounds that have traditionally been related to sensory properties of wines. The synthesis of these secondary metabolites can be influenced by numerous factors, including the edaphoclimatic conditions of the growing area of vines. In this study, the effect of topography and cultivation location on the chemical composition and sensory perception of wines was determined.
View Article and Find Full Text PDFDistinguishing between primary (PID) and secondary (SID) immunodeficiencies, particularly in relation to hematological B-cell lymphoproliferative disorders (B-CLPD), poses a major clinical challenge. We aimed to analyze and define the clinical and laboratory variables in SID patients associated with B-CLPD, identifying overlaps with late-onset PIDs, which could potentially improve diagnostic precision and prognostic assessment. We studied 37 clinical/laboratory variables in 151 SID patients with B-CLPD.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the fatigue performance of a specific titanium alloy (Ti-6Al-4V) made using laser powder bed fusion, focusing on how defects like keyhole porosity and surface roughness affect its durability.
- Researchers used four-point bending tests and examined various surface roughness levels, discovering that fatigue life varied by 10 cycles depending on these factors.
- The findings included S-N (stress-number of cycles to failure) curves which fitted Basquin's stress-life relation for most defects, indicating that keyhole porosity had less impact on fatigue performance compared to other factors in the alloy's manufacturing process.