Publications by authors named "F X Sureda"
Article Synopsis
- Pufferfish, known for being highly toxic due to neurotoxins like tetrodotoxins and paralytic shellfish toxins, poses a serious risk to human health and has caused many poisoning incidents.
- A study analyzed tissue extracts from two pufferfish species collected from the Spanish Mediterranean, revealing no toxicity in Sphoeroides pachygaster but significant toxicity in the liver of Lagocephalus lagocephalus specimens.
- High-performance liquid chromatography analysis confirmed the presence of paralytic shellfish toxins, particularly saxitoxin and decarbamoylsaxitoxin, in L. lagocephalus, highlighting a food safety concern due to the potential risks associated with consuming this toxic fish in the region. *
Article Synopsis
- Tetrodotoxin (TTX) is a dangerous marine neurotoxin linked to various poisoning cases and fatalities, with over 30 known analogues, but their toxic effects are not fully understood.
- This study focused on determining the toxicity equivalency factors (TEFs) of five TTX analogues by examining how they affect voltage-gated sodium channels in Neuro-2a cells using an automated patch clamp method.
- Results showed that all TTX analogues were less toxic than TTX, and the derived TEFs can effectively convert LC-MS/MS data from pufferfish samples into relevant toxicological insights, emphasizing the potential of this method for food safety and health protection.
Pancreatic β-cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here we report that the succinate receptor (SUCNR1) is expressed in β-cells and is up-regulated in hyperglycemic states in mice and humans. We found that succinate acts as a hormone-like metabolite and stimulates insulin secretion via a SUCNR1-Gq-PKC-dependent mechanism in human β-cells.
View Article and Find Full Text PDFTetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification.
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