Publications by authors named "F X Lopez Altimiras"
Article Synopsis
- - The degu is a long-lived rodent that experiences age-related changes similar to human aging, including cognitive decline and brain pathologies resembling Alzheimer's disease.
- - Whole-genome sequencing of the degu revealed specific genetic traits linked to aging and Alzheimer's, including notable variations in genes associated with the disease, such as a new variant of the apolipoprotein E gene.
- - Studying the degu's genome can enhance our understanding of the molecular processes involved in aging and potentially lead to advancements in treatments for Alzheimer's disease.
Article Synopsis
- Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and autism, characterized by synaptic development issues, with mouse models showing symptoms like anxiety and hyperactivity.
- The drug ANAVEX2-73 (blarcamesine), which acts as a sigma-1 receptor agonist, has shown promise in improving cognitive and behavioral issues associated with FXS in mouse studies by normalizing hyperactivity and anxiety-like behaviors.
- The findings suggest that blarcamesine could be a viable treatment option for FXS and potentially other neurodevelopmental disorders due to its effects on synaptic function and receptor activity.
The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder considered the most common cause of inherited intellectual disability and the leading monogenetic cause of autism.
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- Fragile X syndrome (FXS) is a genetic condition linked to intellectual disability and is a major cause of autism spectrum disorder (ASD), with no specific drug treatment available.
- Researchers explored the use of bryostatin-1, a compound that activates certain protein kinases, to see if it could improve autistic behaviors and cognitive deficits in FXS mice.
- Findings showed that longer treatment (13 weeks) with bryostatin-1 significantly improved autistic and cognitive symptoms, highlighting its potential as a valuable long-term therapy for both ASD and FXS without the tolerance issues seen with other drug therapies.
A Db-Scan Binarization Algorithm Applied to Matrix Covering Problems.
Comput Intell Neurosci
September 2020
The integration of machine learning techniques and metaheuristic algorithms is an area of interest due to the great potential for applications. In particular, using these hybrid techniques to solve combinatorial optimization problems (COPs) to improve the quality of the solutions and convergence times is of great interest in operations research. In this article, the db-scan unsupervised learning technique is explored with the goal of using it in the binarization process of continuous swarm intelligence metaheuristic algorithms.
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