Publications by authors named "F X Lescure"
Background: The global mpox outbreak which started in May 2022 was caused by a novel clade IIb variant of the mpox virus (MPXV). It differed from the traditional Western and Central Africa disease in transmission patterns and clinical presentation.
Methods: To address the need for detailed clinical and virologic data, we conducted an observational cohort study (MOSAIC) during May 2022-July 2023 in individuals with confirmed MPXV infection enrolled in six European Countries.
Importance: Infective endocarditis (IE) caused by Staphylococcus aureus is associated with high mortality, approximately 20% to 30%, mostly in the first month, with no improvement in recent decades. Current opinion is that antistaphylococcal penicillin and cefazolin are equally effective in treating methicillin-susceptible S aureus (MSSA) IE, and both are recommended as possible first-line treatments. Most MSSA strains carry the β-lactamase blaZ gene, and some blaZ-positive strains exhibit an inoculum effect, meaning increased minimum inhibitory concentrations at high inoculum.
View Article and Find Full Text PDFAntimicrobial prescribing in French nursing homes and interventions for antimicrobial stewardship: a qualitative study.
Antimicrob Resist Infect Control
November 2024
Article Synopsis
- Overuse of antibiotics in nursing homes often leads to negative outcomes and the rise of resistant bacteria, prompting the need for better antimicrobial stewardship interventions.
- This study conducted interviews with prescribing physicians in nursing homes in France to determine factors influencing antibiotic prescribing, resources used, and necessary interventions.
- Key findings revealed that perceived risks, difficulties in obtaining microbiological samples, and staff shortages contribute to inappropriate prescribing practices, while tailored guidelines and enhanced multidisciplinary communication could improve antibiotic use.
Poliomyelitis in Gaza.
Clin Microbiol Infect
October 2024