Determinants of Orphan Drug Prices in Germany.

Background And Objective: Legislation introduced in 2011 in Germany has instituted an early benefit assessment of newly licensed pharmaceuticals with a subsequent price negotiation. For orphan drugs (ODs) a special legal framework applies, which accounts for the fact that ODs do not have to prove an added benefit over an appropriate comparative therapy previously determined by the decision maker. As, in addition, the content of negotiations between pharmaceutical companies and the payer is confidential, the aim of this study was to identify factors influencing the negotiated prices of ODs.

Different interpretation of additional evidence for HTA by the commissioned HTA body and the commissioning decision maker in Germany: whenever IQWiG and Federal Joint Committee disagree.

Background: The purpose of this study was to analyse the impact of commissioned addenda by the Federal Joint Committee (FJC) to the HTA body (IQWiG) and their agreement with FJC decisions and to identify potential additional decisive factors of FJC.

Methods: All available relevant documents up to end of 2017 were screened and essential content extracted. Next to descriptive statistics, differences between IQWiG and FJC were tested and explored by agreement statistics (Cohen's kappa and Fleiss' kappa) and ordinal logistic regression.

[The influence of macro- and microstructure on the surface wettability and retention properties of endodontic posts in vitro].

Aesthetical and biomechanical requirements on fiber-reinforced endodontic posts play an important role in clinical application. Leading to a long-term clinical success, post systems must ensure an adequate force transmission and optimal retention behavior into the root channel. The aim of this study was to determine the microstructure and morphology of commonly used fiber reinforced endodontic posts in vitro.