Divergence of ethanol and acetaldehyde kinetics and of the disulfiram-alcohol reaction between subjects with and without alcoholic liver disease.

Despite standardization, marked interindividual variation in the severity of the disulfiram-alcohol reaction (DAR) has been observed. We studied the DAR in 51 consecutive alcoholics with (n = 16) and without (n = 35) significant alcoholic liver disease. Clinical signs of the DAR were much weaker in the patients with compared with those patients without liver disease.

[Ambulatory, disulfiram-(Antabuse)-assisted management of the alcoholic patient].

The treatment of patients suffering from alcoholism is notoriously difficult. Ambulatory supportive therapy using disulfiram and supervised by the practicing physician has many advantages. Foremost among these is the maintenance of the patient within his working and social environment.

[Diagnosis and treatment of alcoholism: psychiatric aspects].

The image of the chronic alcohol patient has changed. Diagnosis is only possible if the doctor assumes alcohol abuse in all his patients. The diagnosis can only be made taking psychiatric, somatic and psychosocial aspects into consideration.