Density-profile imaging using a second harmonic dispersion interferometer configured with reflective-beam expanders.

A Second-Harmonic Dispersion Interferometer (SHDI) is assembled to measure the two-dimensional, line-integrated density profile of a pulsed-plasma jet using probe-beam diameters well beyond the 1 mm diameters typically used in such instruments. An initial prototype demonstrated the technique using 7 mm beam diameters, which are now increased to 35 mm diameter using two types of beam expanders: an achromatic-beam expander (ABE) or a reflective-beam expander (RBE). ABEs were found to add a periodic background to the measured-phase image with a magnitude of the order of Δϕ ∼ 2π radians, compared to the background phase noise level in the system configured without beam expanders at Δϕbg ∼ 0.

Measurement of 2D density profiles using a second-harmonic, dispersion interferometer.

A second-harmonic, dispersion interferometer is used to image large-area (≃5 cm) plasma-jet and gas-jet density profiles. Achromatic telescopes magnify the diameters of the primary-laser beam (1064 nm) and its second-harmonic (532 nm) before probing the sample and de-magnify the beam diameters after the sample, where the primary beam transfers its phase change to a second, second-harmonic beam, allowing the sample's dispersive-phase change to be measured between two, orthogonally polarized second harmonic beams. The telescopes produce an azimuthally symmetric, dispersive-phase shift in the sample + background phase-change image and in the background phase-change image, which is removed by digital subtraction.

One-kilojoule pulsed-power generator for laboratory space sciences.

This paper reports on the assembly of a compact, low-cost, pulsed-power facility used for plasma studies. The construction uses two modules placed on opposite sides of the test chamber to minimize the system impedance and improve access to test samples. The stored energy is 1  kJ with a peak current of 135  kA and a 1592  ns quarter-period time.

T cell-mediated elimination of cancer cells by blocking CEACAM6-CEACAM1 interaction.

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small cell lung, pancreatic, and colorectal cancer. CEACAM receptors undergo homo- and heterophilic interactions thereby regulating normal tissue homeostasis and angiogenesis, and in cancer, tumor invasion and metastasis. CEACAM6 expression on malignant plasma cells inhibits antitumor activity of T cells, and we hypothesize a similar function on epithelial cancer cells.

Experimental study on the performances of second-harmonic dispersion interferometers at 10.6 µm and 1064 nm for plasma density measurements.

Two common-path interferometers based on and : (Nd:YAG) lasers are benchmarked with a two-arm microwave interferometer on a hydrogen plasma produced by an RF discharge and injected into a large magnetic-confinement vessel. The ∼10 line-integrated electron density is clearly measured in agreement by the interferometers. The frequency spectrum of the measured data is analyzed on the 20 kHz range for all interferometers and up to 600 kHz for the Nd:YAG laser-based interferometer.