Background: Hemoglobinopathies, the most common inherited blood disorder, are frequently underdiagnosed. Early identification of carriers is important for genetic counseling of couples at risk. The aim of this study was to develop and validate a novel machine learning model on a multicenter data set, covering a wide spectrum of hemoglobinopathies based on routine complete blood count (CBC) testing.
View Article and Find Full Text PDFAnaemia can be subdivided into microcytic, normocytic and macrocytic categories, which give direction to the investigation to identify the cause of the anaemia. However, this is not always straightforward, as this case illustrates. A 73-year-old man with normocytic anaemia appeared to have both beta thalassemia trait (microcytic) and myelodysplastic syndrome (usually macrocytic).
View Article and Find Full Text PDFIntroduction: Hemoglobin-based oxygen carriers, for example HBOC-201 (Hemopure), are aimed to bridge acute anemia when blood transfusion is not available or refused by the patient. However, since HBOC-201 appears free in plasma, it interferes with laboratory tests. This study presents an overview of HBOC-201 interference on four commonly used hematology analyzers and suggests treatment monitoring possibilities.
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