Publications by authors named "F W SUNDERMAN"
Article Synopsis
- The study investigates how management practices and environmental factors affect arthritis in lambs from 122 sheep flocks in Western Australia.
- Visual assessments by meat inspectors diagnosed arthritis, and data on management practices were collected through interviews to analyze their impact.
- Results revealed that mulesing and shearing significantly increased the likelihood of high arthritis prevalence, suggesting these practices should be avoided to improve lamb health.
Human exposure to highly nickel-polluted environments, such as those associated with nickel refining, electroplating, and welding, has the potential to produce a variety of pathologic effects. Among them are skin allergies, lung fibrosis, and cancer of the respiratory tract. The exact mechanisms of nickel-induced carcinogenesis are not known and have been the subject of numerous epidemiologic and experimental investigations.
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- Occupational exposure to certain metal dusts or aerosols can lead to serious health issues, including loss of smell, nasal problems, and even cancer.
- Specific metals like nickel (Ni), cadmium (Cd), chromium (Cr), and arsenic (As) have been linked to these adverse effects in industries like battery manufacturing and chrome plating.
- Metals can travel quickly through the nasal passage to the brain via olfactory nerves, with certain metals accumulating more in the olfactory bulb, though the exact mechanisms of this process are still not fully understood.
Interactions of serine proteinases with pNiXa, a serpin of Xenopus oocytes and embryos.
Biochim Biophys Acta
February 1998
Article Synopsis
- pNiXa, a serpin found in Xenopus oocytes and embryos, effectively inhibits bovine chymotrypsin and porcine elastase, but not bovine trypsin, forming an SDS-resistant complex with chymotrypsin.
- Analyses reveal that the cleavage sites for chymotrypsin and elastase occur near the C-terminus of pNiXa, while trypsin and cathepsin G cut at specific locations near the N-terminus within a unique peptide segment.
- The study enhances understanding of the interaction mechanisms between pNiXa and these serine proteinases, highlighting a potential serpin-like inhibition mechanism and the binding of 63Ni(II) to the His-cluster