Nocturnal Cardiac Arrhythmias in Heart Failure With Obstructive and Central Sleep Apnea.

Background: Both obstructive and central sleep apnea (CSA) may contribute to nocturnal cardiac arrhythmias (NCAs). Data are scarce regarding the prevalence of clinically important nocturnal atrial and ventricular arrythmias in patients with heart failure with reduced ejection fraction (HFrEF) and OSA or CSA.

Research Question: In a cohort of patients with HFrEF, how does the prevalence of NCA compare among those with OSA, CSA, and those with no to mild sleep apnea? Is the severity of OSA or CSA associated with atrial and ventricular NCAs?

Study Design And Methods: This cross-sectional analysis is an ancillary study of the Effect of Adaptive Servo Ventilation on Survival and Hospital Admissions in Heart Failure (ADVENT-HF) trial.

Methodology for the nocturnal cardiac arrhythmia ancillary study of the ADVENT-HF trial in patients with heart failure with reduced ejection fraction and sleep-disordered breathing.

Background: Sleep disordered breathing (SDB) may trigger nocturnal cardiac arrhythmias (NCA) in patients with heart failure with reduced ejection fraction (HFrEF). The NCA ancillary study of the ADVENT-HF trial will test whether, in HFrEF-patients with SDB, peak-flow-triggered adaptive servo-ventilation (ASVpf) reduces NCA. To this end, accurate scoring of NCA from polysomnography (PSG) is required.

The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier.

Purpose: To determine the effect of molecular weight (MW) on the concentration of plasma-derived proteins in aqueous humor and to estimate the plasma-derived and eye-derived fractions for each protein.

Methods: Aqueous humor and plasma samples were obtained during cataract surgery on an institutional review board-approved protocol. Protein concentrations were determined by ELISA and quantitative antibody microarrays.

Continuity of care for women with breast cancer: a survey of the views and experiences of patients, carers and health care professionals.

Purpose Of The Research: The need for continuity of care in the management of women diagnosed with breast cancer is important yet challenging. The aim was twofold; to explore 1) the concept of continuity of care from the perspectives of women diagnosed with breast cancer, their carers and their health care professionals (HCPs), 2) actual experiences amongst these three groups relating to continuity of care.

Methods And Sample: A three-phase cross-sectional survey was conducted involving eight focus group interviews with women who had been diagnosed with breast cancer (n = 47) and structured questionnaires to both carers (n = 33) and HCPs (n = 44).

Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression.

Introduction: Severe injury can cause intestinal permeability through decreased expression of tight junction proteins, resulting in systemic inflammation. Activation of the parasympathetic nervous system after shock through vagal nerve stimulation is known to have potent anti-inflammatory effects; however, its effects on modulating intestinal barrier function are not fully understood. We postulated that vagal nerve stimulation improves intestinal barrier integrity after severe burn through an efferent signaling pathway, and is associated with improved expression and localization of the intestinal tight junction protein occludin.