Publications by authors named "F W Ott"
The Hedgehog (Hh) signaling pathway is essential for maintaining homeostasis during embryogenesis and in adult tissues. In the liver, dysregulation of this pathway often leads to liver cancer development. Recent studies also suggest that disturbances in the Hh pathway can affect liver metabolism in healthy livers through interactions with other signaling pathways, such as the Wnt/β-catenin pathway.
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- Dystonia is a common movement disorder with a complex genetic background, showing significant variability in its clinical presentation and genetics.
- The study involved exome sequencing of nearly 1,924 patients, mainly from two major registries, focusing on those with genetic prescreening negative results and early age at onset.
- Researchers discovered 137 likely pathogenic variants in 51 genes among the patients, with many being novel, highlighting the challenges in diagnosing and understanding the disorder's genetic links.
Here we present a highly customisable image-based fuzzy logic control (FLC) method for pressure-driven droplet microfluidics. The system is designed to position droplets of different sizes in microfluidic chips of varying channel size in the centre of the region of interest (ROI) using two parallel multiple input single output (MISO) FLCs. Overall, 95.
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- - Tenosynovial giant cell tumor (TGCT) is a rare tumor that arises from the synovium in joints and tendon sheaths, often associated with genetic changes involving the CSF1 gene; symptoms like pain and swelling are common but not specific, requiring MRI and biopsy for accurate diagnosis.
- - A case study of a 45-year-old man initially diagnosed with Erdheim-Chester disease was later correctly identified as TGCT through whole exome sequencing, which showed a CSF1::GAPDHP64 fusion; he was treated successfully with pegylated interferon and imatinib, stabilizing his condition.
- - Single-cell transcriptome analysis highlighted seven cell clusters and revealed that neoplastic cells attract macroph
Cellular electron cryo-tomography (cryoET) produces high-resolution three-dimensional images of subcellular structures in a near-native frozen-hydrated state. These three-dimensional images are obtained by recording a series of two-dimensional tilt images on a transmission electron cryo-microscope that are subsequently back-projected to form a tomogram. Key to a successful experiment is however a high-quality sample.
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