Publications by authors named "F W Michelotti"
Evaluating the diagnostic accuracy of fetal scalp blood sampling: A retrospective cohort study.
Eur J Obstet Gynecol Reprod Biol
December 2024
Introduction: Fetal scalp blood sampling (FSBS) can be used as an adjunctive test, in the presence of a pathological intrapartum fetal heart rate trace, to provide evidence of fetal acidaemia. The role of FSBS remains controversial, this study evaluates the diagnostic accuracy of FSBS at determining various adverse neonatal outcomes.
Method: A retrospective cohort analysis of FSBS undertaken < 1 h from birth in a single UK centre in 2016 and 2017.
Article Synopsis
- - Purpose: The study aims to enhance understanding of diabetes by monitoring β-cell mass and function using a combined PET/MRI protocol, which allows for real-time assessment without needing to pre-label isolated cells.
- - Methods: Islets were transplanted into mice, and their mass and function were tracked using PET and MRI at various intervals post-transplant, with validations through additional imaging techniques to ensure accuracy.
- - Results: The imaging approach successfully monitored the growth and function of transplanted islets, showing a promising correlation between in vivo imaging data and validation methods, while highlighting the need for further research to optimize measurement of β-cell function.
Background: During targeted treatment, HER2-positive breast cancers invariably lose HER2 DNA amplification. In contrast, and interestingly, HER2 proteins may be either lost or gained. To longitudinally and systematically appreciate complex/discordant changes in HER2 DNA/protein stoichiometry, HER2 DNA copy numbers and soluble blood proteins (aHER2/sHER2) were tested in parallel, non-invasively (by liquid biopsy), and in two-dimensions, hence HER2-2D.
View Article and Find Full Text PDFThe overexpression and/or amplification of the HER2/neu oncogene has been proposed as a prognostic marker in breast cancer. The detection of the related peptide HER2 remains a grand challenge in cancer diagnosis and for therapeutic decision-making. Here, we used a biosensing device based on Bloch Surface Waves excited on a one-dimensional photonic crystal (1DPC) as valid alternative to standard techniques.
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