Lung transplant referral considerations for individuals with cystic fibrosis.

Purpose Of Review: The cystic fibrosis (CF) Foundation issued guidelines to promote timely lung transplant referral for people with cystic fibrosis (pwCF) in 2019. Since then more has been published to help refine this complex decision. The goal of this review is to summarize the recent literature informing disease severity in CF, barriers to referral for pwCF and guide timely and appropriate lung transplant referrals.

DNA methylation as a transcriptional regulator of the immune system.

DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs.

Predictors of improved functional outcome following inpatient rehabilitation for patients with traumatic brain injury.

Objective: To determine factors associated with response to inpatient rehabilitation treatment among TBI patients.

Setting: Inpatient rehabilitation service at a Level I trauma center.

Participants: Moderate-severe TBI patients ages ≥ 18years old admitted between January 1, 2002 and December 31, 2012.