Publications by authors named "F W Kullenberg"
Cancer continues to pose a significant global health challenge, with gastrointestinal (GI) cancers among the most prevalent and deadly forms. These cancers often lead to high mortality rates and demand the use of potent cytotoxic chemotherapeutics. For example, 5-fluorouracil (5-FU) forms the backbone of chemotherapy regimens for various GI cancers, including colorectal cancer.
View Article and Find Full Text PDFAnakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats.
Basic Clin Pharmacol Toxicol
June 2023
Chemotherapy-induced mucositis, characterized by diarrhoea and villous atrophy, is a severe side effect contributing to reduced quality of life and premature death in cancer patients treated with cytostatics. Despite its high incidence, there is no effective supportive therapy available. The main objective of this study was to determine if the anti-inflammatory drugs anakinra and/or dexamethasone-which have different mechanisms-of-action-might be used to effectively treat idarubicin-induced mucositis in rats.
View Article and Find Full Text PDFStudy protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival.
BMJ Open
November 2022
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major cancer that is often diagnosed in its intermediate stage, with transarterial chemoembolisation (TACE) being the standard treatment, particularly using the drug idarubicin (IDA).
- This clinical trial aims to improve treatment effectiveness by exploring the interplay of local pharmacology, tumor targeting, and HCC biology, utilizing two different doses of IDA in patients with intermediate-stage HCC.
- The study involves detailed analyses like blood and tissue biopsies, PET/MRI scans, and multiple omics approaches to better understand the tumor characteristics and drug response, while ensuring ethical standards and participant consent throughout the research process.
The progression of doxorubicin-induced intestinal mucositis in rats.
Naunyn Schmiedebergs Arch Pharmacol
February 2023
Chemotherapy-induced intestinal mucositis is a severe side effect contributing to reduced quality of life and premature death in cancer patients. Despite a high incidence, a thorough mechanistic understanding of its pathophysiology and effective supportive therapies are lacking. The main objective of this rat study was to determine how 10 mg/kg doxorubicin, a common chemotherapeutic, affected jejunal function and morphology over time (6, 24, 72, or 168 h).
View Article and Find Full Text PDFAd libitum feeding of experimental animals is preferred because of medical relevance together with technical and practical considerations. In addition, ethical committees may require ad libitum feeding. However, feeding affects the metabolism so ad libitum feeding may mask the effects of drugs on tissues directly involved in the digestion process (e.
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