Publications by authors named "F W Jobe"
Article Synopsis
- Mutations in a protein called calreticulin (mutCALR) cause blood disorders known as myeloproliferative neoplasms (MPNs), but there aren’t any treatments specifically targeting this mutation.
- A new antibody called INCA033989 can specifically attack cells with the mutCALR mutation, stopping them from growing and causing problems.
- In tests on mice, INCA033989 not only prevented issues like high blood cell counts but also showed it could help treat the disease without harming normal blood cell production.
Article Synopsis
- Orthopneumoviruses create membrane-less cytoplasmic inclusion bodies (IBs) that aid in the replication, transcription, and translation of their RNA by sequestering translation machinery components within these structures.
- Studies on respiratory syncytial virus (RSV) showed that these inclusion bodies have a bi-phasic structure with distinct functional domains, including granules that concentrate viral mRNA and translation initiation factors.
- The viral M2-1 protein plays a crucial role by interacting with essential translation factors, facilitating their transport and supporting a unique translation environment within the inclusion bodies, even suggesting the presence of ribosomes for translation within these structures.
Viruses routinely employ strategies to prevent the activation of innate immune signaling in infected cells. Respiratory syncytial virus (RSV) is no exception, as it encodes two accessory proteins (NS1 and NS2) which are well established to block interferon signaling. However, RSV-encoded mechanisms for inhibiting NF-κB signaling are less well characterized.
View Article and Find Full Text PDFThe measles virus (MeV), a member of the genus , is an established pathogen of humans. A key feature of morbilliviruses is their ability to spread by virus-cell and cell-cell fusion. The latter process, which leads to syncytia formation in vitro and in vivo, is driven by the viral fusion (F) and haemagglutinin (H) glycoproteins.
View Article and Find Full Text PDFInfections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been exploited as a route of uptake for an antibody-drug conjugate (ADC) that is completely effective against Trypanosoma brucei in the standard mouse model of infection. Recombinant human anti-HpHbR monoclonal antibodies were isolated and shown to be internalised in a receptor-dependent manner.
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