Publications by authors named "F W Ferreira-da-Silva"
Correction: Translational perspectives on the therapeutic potential of Hyptis crenata essential oil terpenes in smooth muscle function.
Planta Med
October 2024
Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function.
Planta Med
October 2024
Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of (). The therapeutic potential of these terpenes present in is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, -pinene, and -pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels.
View Article and Find Full Text PDFAnethole Prevents the Alterations Produced by Diabetes Mellitus in the Sciatic Nerve of Rats.
Int J Mol Sci
July 2024
Anethole is a terpenoid with antioxidant, anti-inflammatory, and neuronal blockade effects, and the present work was undertaken to study the neuroprotective activity of anethole against diabetes mellitus (DM)-induced neuropathy. Streptozotocin-induced DM rats were used to investigate the effects of anethole treatment on morphological, electrophysiological, and biochemical alterations of the sciatic nerve (SN). Anethole partially prevented the mechanical hyposensitivity caused by DM and fully prevented the DM-induced decrease in the cross-sectional area of the SN.
View Article and Find Full Text PDFArticle Synopsis
- LCINS accounts for 20% of lung cancer cases, with the study focusing on the molecular profile of driver genes in Brazilian patients who never smoked.
- The investigation involved studying mutational and gene fusion status in 119 lung adenocarcinomas using advanced sequencing techniques, alongside genetic ancestry analysis.
- Results showed high mutation rates in genes like EGFR and TP53, with significant findings on ancestry influencing mutation patterns, and highlighted that a large percentage of patients have potential targets for effective treatment.
Introduction: Citral is a low-toxicity monoterpene that has a vasodilator effect on various smooth muscles, and The present study aimed to evaluate its vasorelaxant effect on umbilical vessels of normotensive parturients (NTP) and with preeclampsia parturients (PEP).
Method: Segments of human umbilical artery (HUA) and vein (HUV) of NTP or PEP were mounted in a bath to record the force of contraction, under tension of 3.0 gf and contracted with the contracting agents: K (60 mM), 5 -HT (10 μM) and Ba (1-30 mM).