Publications by authors named "F W Albert"
In genotype-by-environment interactions (GxE), the effect of a genetic variant on a trait depends on the environment. GxE influences numerous organismal traits across eukaryotic life. However, we have a limited understanding of how GxE shapes the molecular processes that give rise to organismal traits.
View Article and Find Full Text PDFObjectives: This study aimed to investigate dyssynchronous heart failure in fetuses of mothers with diabetes mellitus (FDM) and fetal controls (FC) using two-dimensional speckle tracking echocardiography (2D-STE) and novel M-mode prototype software (PS).
Methods: In this cohort study 174 fetuses were analyzed, 87 in the FDM-cohort and 87 gestational age-matched fetuses in the FC-cohort. A subgroup of 38 fetuses formed the final case group, with a high median frame rate of approximately 160 frames/s.
Reconstructing functional neuronal circuits is one major challenge of central nervous system repair. Through activation of pro-growth signaling pathways, some neurons achieve long-distance axon regrowth. Yet, functional reconnection has hardly been obtained, as these regenerating axons fail to resume their initial trajectory and reinnervate their proper target.
View Article and Find Full Text PDFBackground: Medical education offers the foundational base for future healthcare professionals, with basic sciences playing a pivotal role in providing essential knowledge and skills for clinical practice. However, the long-term retention and application of this knowledge in clinical practice remain a significant challenge. This systematic review synthesised global evidence from diverse studies on the short / long-term retention and clinical application of basic sciences among medical doctors.
View Article and Find Full Text PDFArticle Synopsis
- Human milk is essential for infant nourishment, but there's limited understanding of how its composition affects infant health.
- A study examined the relationships between maternal genetics, milk gene expression, and the infant microbiome in 310 breastfeeding mother-infant pairs, identifying 482 genetic loci linked to milk characteristics.
- Findings revealed connections between milk components, like interleukin-6, and the gut bacteria of infants, highlighting the importance of genetics in lactation and its impact on maternal and infant health.