Granular cell basal cell carcinoma.

A 69-year-old woman presented with a 2-year history of a slowly growing tumour on the nose. The clinical diagnosis was basal cell carcinoma (BCC) and a complete excision was performed. Histologically, the tumour had the general features of a BCC but with sheets and nests of cells with granular cytoplasmic changes in the centre of the lesion.

[Photodynamic diagnosis and therapy in dermatology. Experience with use of TPPS4 in skin diseases].

Background: Some skin lesions e.g. basal cell carcinomas are sometimes difficult to remove completely and frequent relapses can develop after their imperfect removal.

Necrobiotic xanthogranuloma presenting as a solitary tumor.

We report on a 60-year-old overweight white woman who presented with an asymptomatic flat, hard, yellow-brown subcutaneous plaque on her right hip. A total excision was performed. Histopathologic examination showed all the major features of a necrobiotic xanthogranuloma (NX) involving the entire dermis and subcutis, including areas of necrobiosis with cholesterol clefts, granulomatous infiltrate with some bizarre giant cells, numerous Touton cells, foamy cells, lymphoid follicles with germinal centers, foci of plasma cells, and "Touton cell panniculitis.

[Malignant melanoma of the skin. Epidemiology, risk factors, clinical diagnosis].

The incidence of malignant melanoma of the skin in the white population worldwide is rising and the mortality from this tumour is also rising. It is assumed that this trend will proceed also in coming years. While in 1970 in the Czech Republic 3.