Publications by authors named "F Vorspan"
Treatment of attention-deficit/ hyperactivity disorder (ADHD) in patients with a substance use disorder (SUD) and comorbid ADHD (SUD +ADHD) may have positive effects on the outcome of both conditions, but controversy exists regarding the preferred ADHD treatment in these patients. Little is known about the treatments that are provided for these patients in routine addiction care practice and the factors that are associated with treatment provision. To describe the treatments provided in everyday clinical practice and to explore factors associated with ADHD treatment provision in patients with SUD +ADHD.
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- The increasing legalization of cannabis worldwide has led to a growing need for methods to accurately identify and quantify cannabis consumption, especially through non-invasive means.
- Oral fluid, as an alternative to traditional blood and urine tests, offers advantages such as easier self-sampling and reduced risk of tampering, although it typically requires larger volumes to test effectively.
- The study presents a new method that allows for the quantification of seven cannabinoids from just 20 µL of oral fluid using a specialized sampling device and advanced chemical techniques, achieving precise detection limits suitable for legal and clinical contexts.
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- The study investigates the changes in gray matter (GM) volume in the insula, a brain region linked to addiction, comparing severe alcohol use disorder (sAUD) and severe cocaine use disorder (sCUD).
- Researchers analyzed 12 subregions of the insula using a sample of 50 sAUD patients, 61 sCUD patients, and 36 healthy controls, finding overall lower insula volume in both disorders, particularly in the anterior long gyrus (ALG).
- The results highlight both shared and distinct patterns of insula volume deficits between sAUD and sCUD, suggesting that while the insula is important in substance use disorders, each disorder may have unique characteristics that could inform treatment approaches.
Article Synopsis
- Current treatment options for psychostimulant use disorder (PUD) are lacking, but research suggests that cholinergic mechanisms could play a role in potential treatments.
- The systematic review evaluates the effectiveness of various cholinergic agents in controlled clinical trials for individuals with PUD, focusing on studies involving cocaine and amphetamines.
- Results indicate that most outpatient trials were inconclusive, with only a couple showing some promise in reducing cocaine use, while laboratory trials did not demonstrate significant effects on cravings or treatment efficacy.*
Objectives: Anxiety and depressive symptoms, as well as cognitive dysfunctions, improve with abstinence in individuals with alcohol use disorders (AUD), but less is known about psychotic features. The objective of this study was to evaluate the psychosis proneness in a sample of individuals with severe AUD and potential changes after alcohol withdrawal.
Method: An observational study was conducted, assessing prospectively Peter's Delusional Inventory scale (PDI); anxiety and depression symptoms by MADRS and cognitive functioning by the MoCA at entry in daycare hospital (D0) and after 30 days (D30).