Publications by authors named "F Vernooij"
The current understanding of the RSV-related mortality age distribution in low- and lower-middle-income countries (LMICs) relies on a limited number of disease incidence studies reporting wide age bands, and lacking specificity to Gavi-eligible countries. Understanding the age distribution of RSV-related deaths is crucial for the implementation of RSV interventions in LMICs that rely on support from Gavi. This study aims to provide the age profile of RSV mortality specifically in Gavi-eligible countries.
View Article and Find Full Text PDFCost-Effectiveness of perioperative Vaginally Administered estrogen in postmenopausal women undergoing prolapse surgery (EVA trial): study protocol for a multicenter double-blind randomized placebo-controlled trial.
BMC Womens Health
December 2021
Article Synopsis
- Surgery for pelvic organ prolapse (POP) has high recurrence rates, leading to significant costs and a negative impact on women's quality of life.
- The EVA trial is a multi-center study that evaluates the effectiveness and cost-effectiveness of vaginal estrogen therapy in 300 postmenopausal women undergoing POP surgery.
- The study will measure various outcomes, including symptom improvement and quality of life, over 12 months to determine if estrogen therapy is a beneficial and cost-effective addition to POP surgery.
Background: Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking.
View Article and Find Full Text PDFBackground: Heterotopic pregnancy is a rare but life-threatening situation. This is a situation where a woman has one or more intrauterine pregnancies and at least one ectopic pregnancy.
Case Description: Heterotopic pregnancy was discovered in a 37-year-old woman during a routine ultrasound check.
Aims: The Toll-like receptor 7 (TLR7) is an intracellular innate immune receptor activated by nucleic acids shed from dying cells leading to activation of the innate immune system. Since innate immune system activation is involved in the response to myocardial infarction (MI), this study aims to identify if TLR7 is involved in post-MI ischaemic injury and adverse remodelling after MI.
Methods And Results: TLR7 involvement in MI was investigated in human tissue from patients with ischaemic heart failure, as well as in a mouse model of permanent left anterior descending artery occlusion in C57BL/6J wild type and TLR7 deficient (TLR7-/-) mice.