Publications by authors named "F Verkuil"
Article Synopsis
- The study compares double inversion recovery (DIR) MRI with conventional contrast-enhanced (CE) MRI for visualizing the synovium in the knees of children with juvenile idiopathic arthritis (JIA).
- Results showed that while DIR MRI had a lower confidence score in depicting the synovium compared to CE-MRI, it still provided reliable measurements of synovial thickness, especially in children with knee arthritis.
- The findings suggest that DIR MRI could be a suitable and less invasive alternative to CE-MRI for assessing synovitis in children with JIA, making it a more child-friendly option.
Background: Knowledge on the role of synovial signal intensity (SI) grading on static contrast-enhanced (CE) MRI of the knee for assessment of disease activity in juvenile idiopathic arthritis (JIA) is lacking.
Objectives: To assess the value of synovial SI on static CE-MRI of the knee for evaluation of disease activity in children with JIA.
Materials And Methods: Children with clinically inactive and clinically active JIA who underwent static CE-MRI of the knee were included.
To directly compare and describe the differences between juvenile idiopathic arthritis (JIA) patients and pediatric controls regarding features of the synovial and tenosynovial membrane on contrast-enhanced magnetic resonance imaging (MRI) of the wrist. T1-weighted contrast-enhanced MRI scans of 25 JIA patients with clinically active wrist arthritis and 25 children without a history of joint complaints nor any clinical signs of joint inflammation were evaluated by two readers blinded to clinical data. The synovium was scored at five anatomical sites based on thickening of the synovium (0-3 scale) and synovial enhancement (0-2 scale).
View Article and Find Full Text PDFBackground: Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism. We report, for the first time, the case of a child affected by GS presenting with recurrent episodes of extensive joint inflammation in both knee joints. The aim of this case-report is to describe the clinical presentation as well as the laboratory, radiologic and microscopic features of this unique presentation of GS.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the appearance of the synovial and tenosynovial membranes in pediatric wrists that show symptoms but are not arthritic, using contrast-enhanced MRI.
- It involved 20 children, aged 7.5 to 17.6 years, who were found to have no arthritic or orthopedic issues despite their symptoms and assessed various imaging characteristics.
- The results revealed that a significant percentage had mild to moderate synovial and tenosynovial enhancement, joint fluid, bony depressions, and signs of bone marrow edema, indicating the potential for juvenile idiopathic arthritis-like features even in non-inflamed wrists.