Publications by authors named "F Venuta"
Background: Resection and reconstruction of the carina infiltrated by non-small cell lung cancer (NSCLC) or an airway tumor is a technically demanding operation allowing oncologic radical treatment. Hereby we report the results of a 20-year experience from a high-volume center.
Methods: Carinal resection was performed in 41 patients for NSCLC (n = 32) or primary airway tumor (n = 9).
Background: Early post-operative airway management after laryngo-tracheal surgery is crucial. Acute respiratory failure due to glottis' edema may occur, requiring reintubation. This can prolong ventilatory assistance, jeopardizing anastomosis.
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- Cancer stem cells (CSCs) in lung adenocarcinoma (LUAD) show low levels of reactive oxygen species, making them resistant to ferroptosis, a type of iron-dependent cell death.
- In experiments, LUAD cells in 3D spheroids displayed a switch to a resistant phenotype against the ferroptosis inducer RSL3, while disruption of 3D structure restored their sensitivity to cell death.
- Molecular analyses indicated that this resistance was linked to increased antioxidant gene expression and iron storage proteins, revealing insights into CSC plasticity and potential mechanisms behind drug resistance in tumors.
The general world population is aging and patients are often diagnosed with early-stage lung cancer at an advanced age. Several studies have shown that age is not itself a contraindication for lung cancer surgery, and therefore, more and more octogenarians with early-stage lung cancer are undergoing surgery with curative intent. However, octogenarians present some peculiarities that make surgical treatment more challenging, so an accurate preoperative selection is mandatory.
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