Publications by authors named "F Vely"
Persistent NK cell deficiency associated with pulmonary cryptococcosis.
Ann Clin Microbiol Antimicrob
January 2025
We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.
View Article and Find Full Text PDFPurpose: CTLA4 deficiency is an inborn error of immunity (IEI) due to heterozygosity for germline loss-of-function variants of the CTLA4 gene located on chromosome 2q33.2. CTLA4 deficiency underlies pleiotropic immune and lymphoproliferation-mediated features with incomplete penetrance.
View Article and Find Full Text PDFArticle Synopsis
- Epicardial adipose tissue (EAT) is an active organ related to heart conditions like coronary artery disease and is found surrounding the heart and coronary arteries.
- This study aimed to compare immune cell types in EAT with those in different types of adipose tissue, specifically thoracic subcutaneous, visceral abdominal, and subcutaneous abdominal fat, using samples from patients with heart issues.
- Results revealed a strong link between immune pathways and browning genes in EAT, with notable differences in the presence of adaptive and innate immune cells compared to subcutaneous fat tissues.
Article Synopsis
- The study reviewed publications on patients with gastrointestinal defects and immunodeficiency syndrome-1 (GIDID1) linked to TTC7A abnormalities, analyzing their health outcomes, treatment, and genetic factors.
- Findings revealed a high mortality rate of 65.8% among 83 patients, with an average age of death at about 11.8 months; three phenotypic groups were observed, each with varying mortality rates.
- Genotype associations were identified, particularly the NS/NS and MS/MS variants, linked to specific phenotypes, while limited effective treatments were noted, indicating a need for better therapeutic strategies.
Article Synopsis
- The study explores the relationship between epicardial adipose tissue (EAT) and immune cell characteristics, focusing on how EAT is linked to coronary artery disease and atrial fibrillation, and identifies unique immune signatures associated with browning genes.* -
- Results from the EPICAR and INTERFACE studies show a strong correlation between the T helper cell subtype Th2 immune pathway and browning genes in EAT, with a higher presence of various immune cells, such as CD4 and CD8 T cells, in both EAT and visceral fat compared to subcutaneous adipose tissue.* -
- The research highlights a significant increase in innate lymphoid cells (ILCs) within visceral fat, particularly EAT, and finds a