[Sensitivity to disinfectants in certain rare micromycetes].

The authors investigated the effectiveness of 6 different disinfectants at recommended concentrations on strains of rare types of filamentous micromycetes: Scedosporium apiospermum and Exophiala dermatitidis (isolated from ophthalmomycoses), Fusarium dimerum (isolates from nosocomial fungaemia) and strains of Fusarium moniliforme and Stachybotrys alternans (isolates from the environment and potential producers of mycotoxins). The tested strains were mostly sensitive also to an alcoholic solution, to a preparation containing glutaraldehyde, with inorganic peroxocompounds, with peroxoacetic acid; the lowest effectiveness was found in the preparation containing active chlorine and the most resistant strain was Scedosporium apiospermum.

[Paecilomyces lilacinus--sensitivity to disinfectants].

In conjunction with nosocomial infection of opthalomycoses in the ophthalmological department, from the enucleated eye and from Ringer solution (used during operations) a fibrous microscopic fungus Paecilomyces lilacinus was isolated. During sensitivity tests of the isolated strain to locally used disinfectants and chemical sterilizing agents it was revealed that the strain was not killed even by the action of higher concentrations of disinfectant solutions, used in our health departments according to instructions of the Ministry of Health of the Slovak Republic. Persteril, although supposed to act as a chemical sterilizing agent 0.

[Evaluation of the antimicrobial effect and toxicity of glutaraldehyde].

The antimicrobial efficacy and toxicity of a solution containing 20 g.l-1 glutaraldehyde was evaluated. All the tested germs of gram-negative microorganisms and of the strain Staphylococcus aureus were killed within 5 minutes, those of mycobacteria within 120 minutes, and bacterial spores in the course of 240 minutes.

Hexachlorophene. Secondary microorganism resistance to hexachlorophene. Conjugative transfer inhibition by the R-plasmid-coded resistance by hexachlorophene.

Strain resistance of the genus Escherichia, Salmonella, and Pseudomonas to hexachlorophene is inducible. Secondary resistance of the Gram-negative microorganisms to hexachlorophene is an inherited property of these strains. There are not any explicit differences of primary sensitivity to hexachlorophene between sensitive strains and those resistant to antibiotics.