Publications by authors named "F V Coevorden"
Purpose: Retroperitoneal sarcomas (RPS) are rare, heterogeneous tumours. Treatment recommendations are mainly derived from cohorts treated at reference centres. The applicability of data from cancer registries (CR) is controversial.
View Article and Find Full Text PDFNeoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GISTs) is Effective and Safe: Results from a Prospective Single-Center Study with 108 Patients.
Ann Surg Oncol
December 2023
Article Synopsis
- Neoadjuvant imatinib is an effective treatment for large or locally advanced gastrointestinal stromal tumors (GISTs), as it helps decrease tumor size, leading to more successful surgeries and higher rates of complete tumor removal (R0 resection).
- A study of 113 patients showed that a high percentage (95%) underwent surgery after treatment, with significant tumor size reduction in 88% of cases, particularly in those with specific genetic mutations (KIT exon 11).
- The majority of patients (51%) had their surgical strategy adjusted, with a low complication rate (15%) and promising long-term survival rates (80% disease-free and 91% overall after five years).
Background: The aim of this study was to assess the association between radiological and histopathological response after neoadjuvant radiotherapy (nRT) in soft tissue sarcoma (STS), as well as the prognostic value of the different response evaluation methods on the oncological outcome.
Methods: A retrospective cohort of patients with localized STS of the extremity and trunk wall, treated with nRT followed by resection were included. The radiological response was assessed by RECIST 1.
Background: The etiology of cutaneous angiosarcoma (cAS) may be idiopathic (I-cAS), or arise secondary to radiotherapy (RT-cAS), in chronic lymphedema (ST-cAS), or related to UV exposure (UV-cAS). The aim of this study was to evaluate oncological outcomes of different cAS subtypes.
Patients And Methods: Non-metastatic cAS patients, treated with surgery for primary disease with curative intent, were retrospectively analyzed for oncological outcome, including local recurrence (LR), distant metastases (DM), and overall survival (OS).
Purpose: The aim of this study was to create and validate dynamic nomograms to predict overall survival (OS) and disease-free survival (DFS) at different time points during follow-up in patients who had undergone resection of primary retroperitoneal sarcoma (RPS).
Methods: Patients with primary RPS operated upon between 2002 and 2017 at four and six referral centres comprised the development and external validation cohorts, respectively. Landmark analysis and multivariable Cox models were used to develop dynamic nomograms.