Publications by authors named "F Ubaldi"
Value of PGT-A when only one or two blastocysts are obtained: propensity-score matching and cost-effectiveness study.
Ultrasound Obstet Gynecol
December 2024
Objective: To compare the effectiveness and cost of in-vitro fertilization (IVF) with or without preimplantation genetic testing for aneuploidy (PGT-A) when only one or two blastocysts are obtained.
Methods: A dataset was gathered from 1829 patients including 368 non-PGT-A and 1461 PGT-A cycles with one or two blastocysts obtained, between April 2013 and July 2022. Patients were matched 1:1 by propensity-score matching for maternal age, number of metaphase-II oocytes inseminated and number of blastocysts obtained, achieving a database of 242 patients per group.
Article Synopsis
- The study aimed to explore how sperm quality (based on WHO-2021 criteria) and paternal factors like BMI and age relate to outcomes in ICSI cycles with PGT-A, focusing on clinical and embryological results.
- Conducted at a private IVF clinic, the research included data from 3101 couples over several years, employing techniques like trophectoderm biopsies and chromosome testing to evaluate the success of fertilization and embryo development.
- Results showed that maternal age significantly affected embryo quality, while lower sperm motility and specific conditions like obstructive and non-obstructive azoospermia were linked to poorer outcomes, including live birth rates.
Private medical care has significantly contributed to the advancement of various medical fields. The birth of private IVF groups in the 1990s led to improvements in stimulation protocols, embryo culture, intracytoplasmic sperm injection, vitrification and preimplantation genetic testing. However, infertility is often misunderstood as a disease, leading to low birth rates and a lack of awareness among the general population.
View Article and Find Full Text PDFPurpose: This study is to evaluate the effectiveness of a PPOS protocol in poor prognosis patients undergoing IVF with DuoStim and PGT-A versus the conventional protocol with GnRH antagonist.
Methods: Retrospective cohort study encompassing 444 couples obtained matching one PPOS-DuoStim with two antagonist-DuoStim cycles at a private IVF center between 2020 and 2023 (average maternal age: 40 years, average cumulus-oocyte complexes collected after the first stimulation: 5). The study was powered to exclude a two-sided different euploid blastocyst rate per MII oocytes (EBR per MII) in the two groups (alpha = 0.
Purpose: To assess oocyte competence and embryo chromosomal constitution in phenotype-D PCOS women undergoing ICSI for PGT-A at the blastocyst stage.
Methods: Retrospective study at a private IVF center. In the period 2013-2021, 58 naïve phenotype-D PCOS women (i.